HD-A+VM_(26)+rhG-CSF动员白血病患儿外周血造血干细胞的初步研究  

The stem cell mobilizing capacity of HD-A+VM_ (26)+rhG-CSF for childhood leukemia

作　　者：竺晓凡[1] 陈玉梅[1] 邹尧[1] 王书春[1] 张丽[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液研究所血液病医院,300020

出　　处：《中国小儿血液》2004年第3期125-127,共3页China Child Blood

基　　金：天津市自然科学基金资助 (项目编号 0 0 36 0 74 11)

摘　　要：目的 　评价HD -A +VM2 6+rhG -CSF动员白血病患儿外周血造血干细胞的效果。方法 　 5例高危急性白血病患儿 ,其中急性淋巴细胞白血病 (HR -ALL) 4例 ,急性杂合细胞白血病 (AHL) 1例。年龄 9～ 1 3岁。 5例患儿均采用HD -A +VM2 6+rhG -CSF方案进行动员。在化疗后第 9天应用rhG -CSF ,当白细胞升至 5× 1 0 9/L以上时 ,使用CS - 30 0 0血细胞分离机采集PBSC。结果 　 4例采集 1次 ,1例采集 2次。全部患儿均能耐受该动员方案治疗。MNC值为 5 96 5( 5 0 2～ 7 2 )× 1 0 8/kg。CD3 4+ 细胞量为 4 372 ( 3 95～ 5 6 2 )× 1 0 6/kg。结论 　G -CSF联合大剂量Ara -C和VM2 6的化疗可采集到足够数量的自体外周血干细胞。Objective To investigate the clinical value of rh-G-CSF combined with high-dose Ara-C and VM 26for mobilizing peripheral blood stem cell in children with acute leukemia. Methods 5 patients with acute leukemia accepted rh-G-CSF combined with high-dose Ara-C and VM 26for mobilizing peripheral blood stem cell. The age was 9～13 years old. Four case of high-rish acute lymphoblastic leukemia (HR-All), 1 case of hybrid acute leukemia(HAL). G-CSF was given on day 9 after chemotherapy. When WBC>5×109/L,APBSC were harvested with CS 3000 plus Spectra. Results Four patients were collected one time, one patient two times. All of the patient could tolerate the treatment regimens. The harvested MNC was 5.965(5.02～7.2)×108/kg. CD 34+ cell was 4.372(3.95～5.62)×106/kg. Conclusion rh-G-CSF combined with high-dose Ara-C and VM 26is an optimal method for APBSC mobilization in acute leukemia in childood.

关 键 词：HD-A VM26 rhG-CSF 白血病 外周血 造血干细胞 小儿 阿糖胞苷 替尼泊苷 粒细胞刺激因子 

分 类 号：R733.7[医药卫生—肿瘤]