肝细胞脂肪变性模型形态研究  

Morphological Investigation on the Model of the Hepatocyte Fatty Degeneration

作　　者：苏宝亮[1] 陈真[2] 徐厚明[2] 钱之玉[2] 

机构地区：[1]中国药科大学分析测试中心,南京210009 [2]中国药科大学药理学教研室,南京210009

出　　处：《中国药科大学学报》2004年第4期365-367,共3页Journal of China Pharmaceutical University

摘　　要：目的 :对药物导致肝细胞脂肪变性模型进行研究。方法 :体外培养肝细胞 ,给予 2种药物损伤因子 (乙硫氨酸和四环素 ) ,以扫描电镜观察为指标 ,考察模型组的变化。结果 :各模型组的细胞形态与正常组相比有显著性差异 ,细胞形态不规则、细胞肿胀、细胞膜上有大小不一的孔 ,甚至有的细胞膜不完整和出现破损。结论 :乙硫氨酸和四环素均可不同程度地导致肝细胞的脂肪变性。AIM: To study the model of the drug-induced hepatocyte fatty degeneration. METHOD: The hepatocyte was cultured in vitro and given two damage factors,ethionine and tetracycline and then observed by the scanning electron microscope. RESULT: Significant difference of the hepatocyte morphology was observed in all the model groups,compared with the normal. The cell of model groups was swollen and the shape was changed.The membrane surface was damaged. CONCLUSION: Ethionine and tetracycline can lead to the hepatocyte fatty degeneration at different levels.

关 键 词：脂肪肝 模型研究 扫描电镜 形态学 乙硫氨酸 四环素 

分 类 号：R575.5[医药卫生—消化系统]