促吸剂对胰岛素结肠给药降血糖作用的影响  

Influence of various absorption enhancers on the hypoglycemic effect of insulin via colon delivery

作　　者：徐琛[1] 张钧寿[2] 

机构地区：[1]南京大学生命科学学院,江苏南京210093 [2]中国药科大学药剂教研室,江苏南京210009

出　　处：《中国药理学通报》2004年第8期911-914,共4页Chinese Pharmacological Bulletin

基　　金：南京大学分析测试基金资助项目;NoSK3 2

摘　　要：目的　研究促吸剂对胰岛素溶液 (insulinsolution ,INS SOL)经大鼠结肠给药后的降血糖作用的影响。方法　以血糖水平为指标 ,考察不同促吸剂对INS SOL经结肠给药后降血糖作用的影响并计算药理生物利用度 (pharmacologicalbioavailability ,PA)。结果　含桉油醇、癸酸钠、脱氧胆酸钠和薄荷醇的INS SOL(5U·kg-1)均可降低血糖 (P <0 0 5 ) ,而桉油醇的作用最明显 ,最大降糖百分数为 38 8% (P <0 0 1)。无促吸剂的INS SOL(5U·kg-1)经结肠给药后的PA为9 16 % ,桉油醇、癸酸钠、脱氧胆酸钠可使PA增高 ,桉油醇的作用最明显 ,达到 2 3 4 % (P <0 0 5 )。 1U·kg-1的INS SOL在桉油醇促吸作用下PA最高达到 5 3 2 9% (P <0 0 1)。结论　在桉油醇作用下INSAim Effect of various absorption enhancers on the insulin colonic absorption was investigated. Methods The hypoglycemic effect was examined after colon delivery of INS SOL co administered with various absorption enhancers and the pharmacological bioavailability (PA) was calculated. Results INS SOL (5 U·kg -1 ) containing eucalyptol, sodium caprate, sodium deoxycholate and menthol significantly decreased the blood glucose level ( P <0 05), and eucalyptol appeared to be more effective (38 8%, P <0 01). The PA was about 9 16% after 5 U·kg -1 INS SOL colonic delivery without enhancers, while INS SOL, co administered with eucalyptol, sodium caprate and sodium deoxycholate respectively, increased PA and eucalyptol was more effective with PA of 23 4% ( P <0 05). INS SOL (1 U·kg -1 ) containing eucalyptol had the highest PA of 53 29% ( P <0 01). Conclusion The absorption enhancer, eucalyptol, can improve the colonic absorption of insulin significantly.

关 键 词：胰岛素 桉油醇 吸收促进剂 结肠吸收 降血糖作用 

分 类 号：R-332[医药卫生] R322.45