蝎毒抗癌多肽对X射线照射小鼠免疫功能的影响  

Effect of APBMV on Immunological Function of the Mice with X-ray

作　　者：杨志华[1] 刘培光[1] 温本[1] 孔天翰[2] 

机构地区：[1]广东医学院附属湛江中心人民医院肿瘤中心,湛江524037 [2]广州医学院蛇毒研究所,广州510182

出　　处：《现代临床医学生物工程学杂志》2004年第4期290-291,294,共3页Journal of Modern Clinical Medical Bioengineering

摘　　要：目的　研究蝎毒抗癌多肽 (APBMV)对X射线照射小鼠免疫功能的影响 .方法　小鼠 6 0只 ,随机均分为正常对照组、照射对照组、照射中药组共 3组 ,照射中药组采取腹腔灌注APBMV结合X线照射 .观察各组白细胞计数、脾脏指数、胸腺指数及免疫荧光染色法和流式细胞仪测定外周血T淋巴细胞亚群等指标 .结果　照射对照组的白细胞计数、脾脏指数、胸腺指数、CD4、CD8亚群与其它两组比较均明显下降 (p <0 .0 1) ,而照射中药组虽有下降 ,但与正常对照组对比无显著性差异 .Objective To investigate the effect of antineoplastic polypeptide from buthus martensii venom(APBMV)on immune function in radiated mice with X-ray. Methods 60 mice were average divide randomly into 3 groups: control group,radiotherapy(RT) group and the comparing with RT and APBMV group.WBC count, thymus index, spleen index ,T lymphocyte subsets of in peripheral blood mice were determined by indirect immunofluorescence and flow cytometer were used as the parameters. Results WBC count , thymus index, spleen index ,T lymphocyte subsets of RT group were lower than two irradiated groups(p<0.01).Compared with the normal control group , the results of all parameters on RT+PABMV group were no differences(p>0.05). Conclusions Antineoplastic polypeptide from buthus martensii venom(APBMV) can improve and protect the immune function in radiated mice with X-ray.

关 键 词：蝎毒 多肽 免疫功能 辐射 

分 类 号：R73-36[医药卫生—肿瘤]