一种用于药物释控系统的微针阵列及其制作方法的研究  

Fabrication of microneedle array for drug delivery systems

作　　者：傅新[1] 焦峰[1] 谢海波[1] 

机构地区：[1]浙江大学流体传动及控制国家重点实验室,浙江杭州310027

出　　处：《工程设计学报》2004年第4期192-196,共5页Chinese Journal of Engineering Design

基　　金：国家自然科学基金重点资助项目(59835160);国家自然科学基金资助项目(50175098);浙江省自然科学基金资助项目(501118).

摘　　要：通过皮肤输送药物最大的障碍是皮肤最外层的角质层.传统的静脉注射用针只有刺透皮肤深入到深层组织内部,才能有效地输送药物,这容易引起感染和疼痛,给患者造成很大的不适.介绍了一种采用硅微加工技术制作的微针,它长度适中,既能穿透皮肤的角质层,又刺激不到深层组织的神经,实现无痛注射的目的.其加工工艺是采用硅的HNA(硝酸+氢氟酸+乙酸)腐蚀系统,是一种硅的各项同性的湿法腐蚀方法.Transdermal drug delivery is limited by the extraordinary barrier properties of the stratum corneum, the outer skin. Conventional needles insert across this barrier and into deeper tissue to effectively deliver drug, but can lead to infection and cause pain,thereby reducing patient compliance. The authors have microfabricated very short microneedles that are sufficiently long to penetrate through the stratum corneum, but short enough not to stimulate nerves in deeper tissue and thus should be painless. These microneedle are created with HNA(HNO\-3+HF+CH\-3COOH) etching system, a silicon isotropic wet etching.

关 键 词：硅 微细加工 湿法腐蚀 各项同性腐蚀微针 透皮给药系统 药物释控系统 

分 类 号：TH77[机械工程—仪器科学与技术] TH16[机械工程—精密仪器及机械]