硒与胃癌关系的研究  

The relationship between selenium and gastric cancer

作　　者：史奎雄[1] 马冠生[1] 张廷雨[1] 程五凤[1] 毛达娟[1] 潘碧霞[1] 许秀娴 

机构地区：[1]上海第二医科大学,上海200025

出　　处：《核技术》1993年第2期107-110,共4页Nuclear Techniques

摘　　要：用Ames方法测定了硒和硒酵母对MNNG诱发TA100致突变作用的抑制效果,并用原子吸收分光光度计测定12例浅表性胃炎(SG)、17例萎缩性胃炎(CAG)、6例不典型增生(Dys)和12例胃癌(GC)病人的头发、血液和部分患者胃液中的硒含量,并用气相-热能分析仪测定了胃液中的亚硝胺含量。结果表明:硒和硒酵母有抑制MNNG对TA100的致突变作用,抑制率分别为66.5％和37.9％;患者的血清硒、发硒和胃液硒的含量随胃粘膜病变程度的加重而降低;SG与GC之间差异非常显著(p<0.01),而亚硝胺的含量SG明显低于CAG、Dys及GC。应用硒酵母给予患者补充硒(150μg/d),观察到血硒含量有明显提高,MnSOD及LPO下降,NK细胞活性增加和胃镜病理活检有好转的变化。Both sodium selenite and selenium yeast were chosen to block the MNNG mutagenesis. The inhibition rates were 66.5% and 37.9% respectively. The selenium levels in hair, serum and gastric juice, and the contents of nitrosamines in gastric juice were also determined. The results showed that the selenium levels were SG>CAG and Dys>GC (p<0.01), and the contents of nitrosamines were SG>G, Dys and GC (p<0.05). 19 cases of CAG patients treated with selenium yeast and 16 cases of the control were observed. After 10 weeks, the selenium levels in serum for the treated group were significantly increased. The symptoms of CAG patients seemed to be alleviated.

关 键 词：硒 胃肿瘤 亚硝胺 抑制 肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]