载脂蛋白Eε_4等位基因是迟发性Alzheimer病的危险因子  

APOLIPOPROTEIN Eε_4 ALLELE IS A RISK FACTOR FOR LATE - ONSET ALZHEIMER DISEASE

作　　者：王传馥[1] 马永兴[1] 王赞舜[1] 陆佩芳[1] 谢素珍[1] 俞正炎[1] 顾跃娣[1] 张建刚[2] 贺林[2] 

机构地区：[1]华东医院上海市老年医学研究所,上海市200040 [2]中国科学院上海生命科学研究中心

出　　处：《老年医学与保健》1999年第1期17-18,24,共3页Geriatrics & Health Care

摘　　要：目的 研究载脂蛋白E等位基因型和迟发性Alzheimer病的关系.方法 在上海地区选取一般健康汉族老年人200人作为正常对照,迟发性Alzheimer病(LOAD)病人51人作为观察对象,研究载脂蛋Eε_4等位基因频率和LOAD的关系.结果在LOAD病人组和正常对照组中,载脂蛋白Eε_4等位基因频率分别为18.6%和7.7%,P=0.0046.结论研究证明载脂蛋白Eε_4等位基因是上海地区汉族人LOAD的危险因子.Objective To study the relationship between the genotype frequency of APOEε4 allele and late - onset Alzheimer disease (LOAD) . Methods 200 cases of apparent healthy elderly as normal control and 51 cases of LOAD as observing subject were selected. All cases were Han nationality lived in Shanghai area. The APOEε4 allele was tested and analyzed.Results The frequency of APOEε4 allele in the LOAD group(18.6%) was significantly higher than that in the control group (7.7%), P = 0.0046. Conclusions APOEε4 allele is a risk factor for LOAD in Han nationality Chinese in Shanghai.

关 键 词：载脂蛋白Eε4 迟发性 ALZHEIMER病 危险因子 正常 等位基因 病人 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R651.15[医药卫生—临床医学]