大豆异黄酮对去势大鼠骨密度和生物力学的影响  

INFLUENCE OF SOYBEAN ISOFLAVONES ON BONE DENSITY AND BIOMECHANICAL PROPERTIES IN OVARIECTOMIZED RATS

作　　者：江和源[1] 秦林林[2] 台建祥[3] 吕飞杰[3] 马海波[2] 陈金标[2] 

机构地区：[1]中国农业科学院茶叶研究所农业部茶叶化学工程重点开放实验室,杭州310008 [2]中日友好医院临床医学研究所,北京100026 [3]中国农业科学院,北京100081

出　　处：《营养学报》2004年第5期370-373,共4页Acta Nutrimenta Sinica

摘　　要：目的:研究大豆异黄酮(SI)防治去卵巢大鼠骨质疏松的作用。 方法:将4月龄雌性SD大鼠摘除大鼠卵巢,按体重随机分成4组各10只。A组:伪手术组、B组:模型组、C组:低剂量异黄酮组、D组:高剂量异黄酮组。连续灌胃饲养2.5月后,断头法处死大鼠,采集左股骨、右股骨、右胫骨、子宫并称重。大鼠右股骨用于测量骨密度,左股骨用于测量骨生物力学指标。 结果:实验期结束,B、C组大鼠体重均高于A组,差异达到极显著水平;D组与A组相近。A组大鼠子宫最重,B组子宫最轻,C和D组居中,差异均达到显著或非常显著水平。B组大鼠骨密度值最低,A组最高,C和D组居中,但各组间差异不显著。B组大鼠左股骨的结构力学指标,多低于其它组,材料力学指标,C和D组高于B组,与A组相当。结论:大豆异黄酮具有改善去卵巢大鼠骨生物力学特性和可能提高骨密度的作用,但骨密度的差异未达到显著水平。Objective: To study the preventive effects of soybean isoflavones (SI) on osteoporosis of ovariectomized rats. Methods: SD female rats, 4 mo old, were ovariectomized and randomized into 4 groups: group A, sham-operated; group B,C, D, ovariectomized; group A,B,i.g. water; group C, i.g. low dose SI; group D, i.g. high dose SI. All rats were killed after 2.5 mo. The weight of womb, bone density and biomechanical properties of femur and tibia were measured. Results: After 2.5 month, the weight of the rats of groups B, C was significantly higher than group A. group D was similar to group A. The rats of group A had the heaviest wombs, and groups B lightest, groups C and D significantly higher than group B. The rats of group B had the least bone density, and group A highest, the other groups in the middle. But all of them were statistically insignificant.The structural parameters of left femur of group B were lower than the others. For biomechanical properities, group C and D were higher than group B and similar to group A. Conclusion: Soybean isoflavones can improve the bone biomechanical properties and might increase bone density of ovariectomized female rats.

关 键 词：大豆异黄酮 钙 去卵巢大鼠 生物力学 骨密度 

分 类 号：R151.1[医药卫生—营养与食品卫生学]