皮下埋植式动脉化疗联合咖啡因治疗恶性骨肿瘤的临床观察  

Clinical observation on intra-arterial chemotherapy by subcutaneous implantaMe delivery system combined with caffeine for treatment of the malignant bone tumors

作　　者：李鼎锋 王磊 崔秋 范海涛 周举 张平 

机构地区：[1]解放军第三○七医院骨科,北京100039

出　　处：《中国肿瘤临床与康复》2004年第5期413-415,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的 探讨皮下埋植式动脉化疗联合咖啡因(CF)治疗恶性骨肿瘤的临床疗效及影像学、病理改变。方法 对64例ⅡB期原发恶性骨肿瘤及13例骨转移癌患者采用皮下埋植式动脉介入化疗系统,以顺铂(DDP)100-120 mg/m2为主,联合咖啡因(CF)1-1.5g/m2/24 h治疗。结果 骨痛总有效率为97.4％,骨病变影像学改变总有效率为71.4％,病理中重度以上化疗反应发生率为85.0％。平均随访30个月,生存率85.0％。结论 本疗法对恶性骨肿瘤临床、影像、病理疗效良好;CF能明显增强DDP的抗肿瘤作用。Objective To evaluate the clinical efficacy of intra-arterial chemotherapy by subcutaneous im-plantable drug delivery system combined with caffeine(CF) in the treatment of the malignant bone tumor and the image and pathological changes after the treatment. Methods Sixty-four stage-Ⅱ B malignant bone tumor cases and thirteen metastatic bone tumor cases were treated with cisplatin( DDP) 100-120 mg/m2 and caffeine (1-1.5 g/m2/24 h) infused by subcutaneous implantable intra-arterial drug delivery system. Results Total effective rate(RR) of relieving pain was 97.4%, the rate of changes in bone image(RR) was 71.4% , medium to severe chemotherapy reaction of pathological changes was 85.0% ,and average follow-up period was 30 months. The survival rate was 85.0%.Conclusion The clinical, image and pathological change efficacy of this chemotherapy in treatment of malignant bone tumor are definite. CF can strengthen the antineoplastic effect of the DDP.

关 键 词：骨肿瘤 埋植式介入化疗 咖啡因 

分 类 号：R738.1[医药卫生—肿瘤] R730.53[医药卫生—临床医学]