取代芳烃对发光菌的毒性及定量结构与活性相关  

TOXICITY OF SUBSTITUTED AROMATIC COMPOUNDS TO PHOTOBACTERIUM PHOSPHOREUM AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS

作　　者：赵元慧[1] 王连生[1] 于红霞[1] 高鸿[2] 

机构地区：[1]南京大学环境科学系,210008 [2]南京大学化学系

出　　处：《环境科学学报》1993年第4期442-449,共8页Acta Scientiae Circumstantiae

基　　金：国家自然科学基金资助课题

摘　　要：通过测定取代芳烃对发光菌毒性,用Free-Wilson法和分子连接性法研究了取代芳烃结构与活性的相关性,取代基的毒性顺序为:-Br>-COOH>-NO_2≈-Cl>-CH_3>-NH_2.建立了EC_(50)与LC_(50)的相关性,并预测了一些化合物的LC_(50)值,结果和实测值符合较好.The toxicities of substituted aromatic compounds to photobacterium phos-phoreum were studied. Relationships between structure and activity of organic compounds were examined by Free-Wilson and Molecular connectivity methods. The order of toxicity contributions for six substituents investigated is as follows. - Br>-COOH>-NO2≈-Cl>-CH3 >-NH2. The relationship between EC50 and LC50 was established. LC50 values were predicted by the EC50 values. The predicted LC50 values are close to those observed.

关 键 词：结构 活度 发光细菌 取代芳烃 毒性 

分 类 号：X172[环境科学与工程—环境科学]