ApoE基因多态性与阿尔茨海默病及血管性痴呆的关系(英文)  

Relationship of the polymorphism of Apolipoprotein E gene with Alzheimer disease and vascular dementia

作　　者：陈谊[1] Olivier HANON Francoise FORETTE 

机构地区：[1]上海第二医科大学附属第九人民医院老年科,上海市200011 [2]法国巴黎BROCA老年医疗中心

出　　处：《中国临床康复》2004年第31期7014-7015,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:研究发现阿尔茨海默病与染色体的病理基因可能有关,而位于19号染色体上ApoE基因与阿尔茨海默病及血管性痴呆发病的关系仍不确切。目的:评价ApoEe4基因与阿尔茨海默病及血管性痴呆的关系,探讨其在预后评估中的应用价值。设计:以诊断为依据的非随机对照研究。地点和对象:选择1996-01/2000-12法国巴黎BROCA医院记忆障碍门诊的老年患者1560例,均为白种人。共分为3组:非痴呆组845例(认知功能正常者及轻度认知功能障碍者);阿尔茨海默病组618例;血管性痴呆组97例。主要观察指标:ApoE等位基因在各组中的检出情况;阿尔茨海默病与血管性痴呆独立危险因素分析。结果:在阿尔茨海默病组中携带E4等位基因的患者为309例,占此组的50%,与非痴呆组比较(240例),差异有显著性意义(P<0.01)。多因素采用回归分析法分析后发现:ApoEe4、年龄、女性是阿尔茨海默病发病的独立危险因素。ApoEe4不是血管性痴呆的独立危险因素(P=0.69)。结论:ApoEe4与阿尔茨海默病有显著相关,是其发病的一个重要危险因素,但与血管性痴呆的关系仍不明确。BACKGROUND:Researches find that Alzheimer disease(AD) may relate with the pathological gene in chromosome;However,the relationship between Apolipoprotein E(ApoE) gene that located on No.19 chromosome and the onset of AD and vascular dementia (VD) is still not clear. OBJECTIVE:To evaluate the relationship between ApoEe4 gene and AD and VD for the discussion of its application merits in the evaluation of prognosis. DESIGN:A non-randomised and controlled study based on diagnosis. SETTING and PARTICIPANTS:A total of 1 560 ageing patients from the outpatient Department of Dysmnesia of BROCA Hospital (Paris, France) were selected from January 1996 to December 2000. All cases were Caucasians,which were divided into three groups:non-dementia group(n=845,patients with normal cognitive function or mild cognitive dysfunction),AD group(n=618) and VD group(n=97). MAIN OUTCOME MEASURES:The detective rate of ApoE alleles of each group, analysis of the independent risk factors of AD and VD. RESULTS:A total of 309 cases in AD group(50%) carried E4 alleles,which was significantly different from that of 240 cases in non-dementia group(P< 0.01). Multiple factors were analysed by regression analysis with the results of that ApoEe4, age and female are the independent risk factors of AD; However, ApoEe4 is not the independent risk factor of VD (P=0.69). CONCLUSION:ApoEe4 significantly correlates with AD, which is an important risk factor of AD genesis; However, the relationship between ApoEe4 with VD is still unclear.

关 键 词：阿尔茨海默病 血管性痴呆 独立危险因素 发病 APOE基因 诊断 等位基因 结论 发现 法国巴黎 

分 类 号：R749[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]