攻击性驾驶行为与单胺氧化酶A基因多态性的关系  

Association between the functional monoamine oxidase A gene polymorphism and aggressively driving behavior

作　　者：李凤芝[1] 李昌吉[1] 龙云芳[1] 詹承烈[1] 姚武[1] 唐海丰[1] 靳辉[1] 

机构地区：[1]四川大学华西公共卫生学院劳动卫生教研室,成都610041

出　　处：《中华预防医学杂志》2004年第5期321-323,共3页Chinese Journal of Preventive Medicine

摘　　要：目的　探讨汽车驾驶员攻击性驾驶行为与单胺氧化酶A基因启动区可变数串联重复多态性的关系。方法　对 348例汽车驾驶员进行驾驶愤怒、驾驶报复、驾驶攻击问卷调查 ,根据量表得分 ,从中选择高、低攻击性驾驶员各 88人 ,采用聚合酶链反应 (PCR)和 3%琼脂糖电泳技术 ,检测MAOA基因启动区内含 30bp碱基的可变数串联重复多态性 ,并统计不同基因型在驾驶员中的分布。结果　发现 2种等位基因 ,分别是由 3个和 4个 30bp基因片段重复形成。这 2种等位基因在高、低攻击性驾驶员中的分布不均衡 ,与低攻击性驾驶员比 ,高攻击性驾驶员中含有 3个 30bp碱基的可变数串联重复多态基因型的构成比为 71 6 % (6 3/ 88) ,非常显著高于含有 4个 30bp碱基的可变数串联重复多态 (2 5 / 88) ,表明攻击性驾驶者含有较多的 3个 30bp碱基的可变数串联重复多态基因型。结论　攻击性驾驶行为可能与MAOA基因启动区可变数串联重复多态性有关 ,基因对攻击性驾驶行为的影响程度尚有待于进一步研究。Objective This study is purposed to explore the relationship between aggressively driving behavior and functional polymorphism in the promoter region of the monoamine oxidase-A(MAOA)gene. Methods A total of 348 automobile drivers were investigated with Deffenbacher’s driver anger scale, driving vengeance questionnaire (DVQ) and driver aggression behavior questionnaire. Eighty-eight drivers were selected as more, medium and less aggressive group, each. Polymerase chain reaction (PCR) and 2.5% agarose gel electrophoresisi were adopted to detect the polymorphism of functional 30 bp-uVNTR in the promoter region of the X-chromosomal MAOA gene and their frequencies of varied genotypes were estimated. Results Two alleles with 3 and 4 repeats of 30 bp-uVNTR were detected in the drivers. Among the more aggressive group, number of the allele with 3 repeats of 30 bp-uVNTR (63/88) was significantly more than that with 4 repeats (25/88)(χ2=10.21, P<0.01), and number of the allele with 4 repeats of 30 bp-uVNTR was more in the less aggressive group, indicating that persons with allele of 3 repeats of 30 bp VNTR were more aggressive in their driving than those with 4 repeats. Conclusions Aggressively driving behavior in drivers possibly related to their functional MAOA-uVNTR polymorphism. Effect of the gene on aggressively driving behavior should be further studied.

关 键 词：单胺氧化酶 基因多态性 等位基因 基因型 琼脂糖电泳 基因启动 构成比 攻击性 变数 得分 

分 类 号：R394[医药卫生—医学遗传学]