血清中Interleukin-18含量的检测对结肠癌预后判断的价值  

Significance of Serum Interleukin-18 in the Prognosis of Colorectal Carcinoma

作　　者：韩明勇[1] 钟伟[1] 郭其森[1] 贾慧[1] 安源[1] 

机构地区：[1]山东省肿瘤医院内二科,250117

出　　处：《实用癌症杂志》2004年第3期268-270,共3页The Practical Journal of Cancer

摘　　要：目的　探讨结肠癌患者血清中白细胞介素 18(IL 18)水平与预后的关系。方法　收集 10 6例结肠癌患者和 60例健康成人的血清 ,采用酶联免疫吸附反应 (ELISA )检测IL 18的水平。结果　 1997年 6月及以前的血清 5 9份 ,IL 18的平均含量为3 3 8.46pg/ml ;1997年 6月以后的血清 47份 ,IL 18的平均含量为 3 2 8.85 pg/ml ;2组比较无显著性差异 (P <0 .0 5 ) ;结肠癌组患者血清IL 18的含量 ( 3 46.5 3 pg/ml± 3 1.2 3pg/ml)明显高于正常对照组 ( 2 3 3 .3 2 pg/ml± 2 2 .5 4pg/ml) ,有显著性差异 (P <0 .0 5 ) ;Ⅱ期、Ⅲ期和Ⅳ期患者血清中IL 18水平明显高于对照组 (P <0 .0 5 ) ,血清IL 18≥ 3 46pg/ml组的患者 5年生存率为 5 .3 % ,血清IL 18<3 46pg/ml的患者 5年生存率为 18.6% ;两组比较有显著性差异 (P <0 .0 5 ) ;多因素分析表明 ,血清IL 18含量是判断结肠癌患者预后的独立因素。结论　血清中IL 18含量与结肠癌患者 5年生存率有密切相关。血清中ILObjective To investigate the significance of serum IL-18 in the prognosis of colorectal carcinoma.Methods The serum IL-18 was detected by enzyme-linked immunosorbent assay(ELISA) in 106 cases of colorectal carcimoma and 60 healthy control.Results The mean serum IL-18 level was 338.46 pg/ml in patients before June 1997 and 328.85 pg/ml in patients after June 1997,showing no significant difference between them(P>0.05).The mean serum IL-18 level was significantly higher in patients with colorectal carcinoma than in the healthy control(P<0.05).The serum IL-18 was much higher in patients with StageⅡ,stage Ⅲ and stage Ⅳ disease than in the healthy control(P<0.05).The 5-year survival rate was 5.3% for patient with serum IL-18 ≥346 pg/ml(n=47),and 18.6% for patients with serum IL-18 <346pg/ml(n=57),showing a significant difference between them.Multivariate analysis using a Cox proportional hazards model identified the serum IL-18 as an independent prognostic factor for patients survival in colorectal carcinoma.Conclusion The serum IL-18 level has a close correlation with the survival curve and may be an important postoperative prognostic indicator in colorectal carcinoma.

关 键 词：血清 INTERLEUKIN-18 含量检测 结肠癌 IL-18 酶联免疫吸附反应 肿瘤 

分 类 号：R735.35[医药卫生—肿瘤]