天然植物提取物对变链菌胞外多糖的抑制  

The inhibition of herb extraction on glucan synthesis

作　　者：李鸣宇[1] 朱彩莲[1] 刘正[1] 

机构地区：[1]上海第二医科大学附属第九人民医院上海市口腔医学研究所,200011

出　　处：《现代口腔医学杂志》2004年第6期481-482,共2页Journal of Modern Stomatology

摘　　要：目的　寻找对控制牙菌斑有效的天然植物提取物。方法　常规细菌培养 ,酚 -硫酸法测细菌培养液的葡聚糖。结果　对水不溶性葡聚糖合成抑制超过 4 0 %的有丁香酚 ,茶多酚 ,蛇床子素 ,芦荟甙 ,齐墩果酸 ,胡椒碱 ,三七皂甙 ,对水溶性葡聚糖合成抑制超过 4 0 %的有丁香酚 ,绿原酸 ,大黄素 ,植酸。对水不溶性葡聚糖和水溶性葡聚糖合成抑制的效果相对都比较好的是丁香酚、胡椒碱、茶多酚。结论　丁香酚、胡椒碱、茶多酚推荐为进一步开发研究的首选药物 ,可望在口腔疾病的防治方面发挥作用。Objective To search the efficiency of herb extraction, which could be used in toothpaste for preventing caries.Methods Efficiency substance was extracted from herbs and identified by glucan synthesis tests.Results Eugenol,Tea polyphenol,Barbaloin, Oleanolic ac id, Chavicin,Sanchi Saponin showed over 40% inhibition effect to insoluble glu c an synthesis. Eugenol, chlorogenic acid,Emodin,tannic acid showed over 40% in hibition effect to soluble glucan.ConclusionThe extracted Eugenol and Tea polyphenol are eff icient and economical for inhibiting glucan synthesis. It may be a relatively id eal natural agent for oral care product that both decreases incidence of caries and maintains the balance of oral ecology system.

关 键 词：天然植物提取物 变链菌 胞外多糖 抑制 牙菌斑 

分 类 号：R780.1[医药卫生—口腔医学]