抗氧化剂维生素E及其代谢物的毒理损伤  

The toxicity of antioxidative V_E and its metabolites

作　　者：肖玉梅[1] 张曙生[1] 覃兆海[1] 李楠[1] 

机构地区：[1]中国农业大学理学院,北京市海淀区圆明园西路2号100094

出　　处：《中国油脂》2004年第11期46-48,共3页China Oils and Fats

摘　　要：从维生素E及其在抗氧化历程中产生的代谢物的分子结构与功能入手 ,综述了新近发现的维生素E及其代谢物的毒理损伤 ,包括与心肌梗塞、高血压及肝硬化等疾病的产生关系密切。因此 ,在使用抗氧化剂时 ,应注意 :①重新建立一套安全评估方案 ;②从分子水平更详尽地了解抗氧化剂的动力学变化和分子转化 ,以此对其利弊作出正确评估 ;③从生物动力学与生物效果模型中找出最佳食用剂量。Based on introducing the structure and the biological effects of vitamin E and its metabolites,the toxicity of vitamin E and its metabolites were reviewed. The toxicity included that vitamin E and its metabolites were involved in myocardial infraction, hypertension and hepatocirrhosis, etc.Many recommendations were put forward when use antioxidants: ①The safety evaluation of food supplements demands another new approach② More understanding on the biokinetics and biotransformation of molecular aspects of antioxidants will enable accurate risk and benefit analysis③Dosage will be optimized on bio-kinetic/ bio-efficacy modeling.

关 键 词：维生素E 毒理 代谢物 抗氧化剂 损伤 心肌梗塞 高血压 分子水平 剂量 疾病 

分 类 号：TS201[轻工技术与工程—食品科学]