SEN virus does not affect treatment response in hepatitis C virus coinfected patients but SEN virus response depends on SEN virus DNA concentration  

作　　者：Abdurrahman Sagin Ortwin Adams OliverKirschberg AndreasErhardt TobiasHeintges Dieter Hussinger 

机构地区：[1]Klinik fr Gastroenterologie,Hepatologie und Infektiologie,Universittsklinikum Dsseldorf,Moorenstr 5,40225 Dsseldorf,Germany [2]Institut fr Virologie der Heinrich-Heine-Universitt Dsseldorf,Moorenstr 5,40225 Dsseldorf,Germany

出　　处：《World Journal of Gastroenterology》2004年第13期1893-1897,共5页世界胃肠病学杂志（英文版）

摘　　要：AIM: To clarify the effect of SEN virus (SENV) infection on a combination therapy including interferon alfa (IFN-α) or pegylated-IFN with ribavirin in patients with chronic hepatitis and the effect of a combination therapy on SENV.METHODS: SENV DNA was determined by polymerase chain reaction in serum samples from 95 patients with chronic hepatitis C. Quantitative analysis was done for SENV H DNA.RESULTS: Twenty-one (22%) of 95 patients were positive for SENV DNA. There was no difference in clinical and biochemical parameters between patients with HCV infection alone and coinfected patients. The sustained response rate for HCV clearance after combination therapy did not differ between patients with SENV (52%) and without SENV(50%, n.s.). SENV DNA was undetectable in 76% of the initially SENV positive patients at the end of follow-up. SENV H response to combination therapy was significantly correlated with SENV DNA level (P=-0.05).CONCLUSION: SENV infection had no influence on the HCV sustained response rate to the combination therapy.Response rate of SENV to the combination therapy depends on SENV DNA level.AIM:TO clarify the effect of SEN virus (SENV) infection on a combination therapy including interferon alfa (IFN-α) or pegylated-IFN with ribavirin in patients with chronic hepatitis and the effect of a combination therapy on SENV. METHODS:SENV DNA was determined by polymerase chain reaction in serum samples from 95 patients with chronic hepatitis C.Quantitative analysis was done for SENV H DNA. RESULTS:Twenty-one (22%) of 95 patients were positive for SENV DNA.There was no difference in clinical and biochemical parameters between patients with HCV infection alone and coinfected patients.The sustained response rate for HCV clearance after combination therapy did not differ between patients with SENV (52%) and without SENV (50%,n.s.).SENV DNA was undetectable in 76% of the initially SENV positive patients at the end of follow-up.SENV H response to combination therapy was significantly correlated with SENV DNA level (P=0.05). CONCLUSION:SENV infection had no influence on the HCV sustained response rate to the combination therapy. Response rate of SENV to the combination therapy depends on SENV DNA level.

关 键 词：Adult Antiviral Agents DNA Virus Infections DNA Viruses purification DNA  Viral Drug Therapy  Combination Female HEPACIVIRUS Hepatitis C  Chronic Humans Interferon Alfa-2a INTERFERON-ALPHA Male Middle Aged Polyethylene Glycols Prevalence RNA  Viral RIBAVIRIN 

分 类 号：R512.63[医药卫生—内科学]