奇可力多糖抗肿瘤作用的实验研究  

The Experimental Study of CPS Anti-tumor

作　　者：陈立阁[1] 昌友权[1] 郑鸿雁[2] 马金荣[3] 昌喜涛[3] 

机构地区：[1]吉林工程技术师范学院生物与食品工程系,吉林长春130052 [2]吉林农业大学食品工程学院,吉林长春130118 [3]吉林省白城中心医院,吉林白城137000

出　　处：《食品科学》2004年第11期276-280,共5页Food Science

摘　　要：目的:探讨奇可力多糖(CPS)抗肿瘤作用并初步探讨其抗肿瘤机制,为其临床应用提供实验室依据。方法:将接种肿瘤后的小鼠随机分为5组,每组10只小鼠,雌雄各半,给药10D,停药后24h处死动物,称鼠体重,剥离小鼠右腋下皮下组织,摘出肿瘤,称瘤重,测定生化指标。结果:对肉瘤(S180)、肝癌(Hep)、胃癌(MFC)细胞荷瘤小鼠肿瘤生长具有明显的抑瘤作用,其中对S180作用显著,较低剂量即可显示明显作用;延长 S180荷瘤鼠生存时间;同时可增加吞噬指数a、廓清指数K及胸腺系数;对体外淋巴细胞转化功能亦有增强作用。结论:CPS具有明显抗肿瘤活性。Objective: Discuss about the anti-tumor effect and mechanism of Chicory Polysaccharide(CPS), which provides thebasis of clinical application. Method: Divide mice (injected by tumor cell) into 5 groups randomly, each group has 10 mice, inwhich both male and female take one half. Administer Chicory Polysaccharide(CPS) 10 days continuously. 24h after administration,kill and weigh them. Separate and weigh tumors in right axillary fossa in mice. Result: Chicory Polysaccharide(CPS) inhibitgrowth of sarcoma S180, liver carcinoma HEP and gastric carcinoma MFC cell bearing tumor mice obviously, it can suppress thegrowth of S180 significantly and prolong the survival time even at a lower dose. Meanwhile, it can increase the phagocyte indexA, expuragation index K, thymus coefficient and increase the transform function of the lymphocyte in vitro. Conclusion: ChicoryPolysaccharide(CPS) has obvious effect on anti-tumor.

关 键 词：抗肿瘤作用 S180 小鼠 临床应用 多糖 实验研究 抗肿瘤机制 接种 动物 体重 

分 类 号：TS727[轻工技术与工程—制浆造纸工程] R285.5[医药卫生—中药学]