实验性过敏性脑脊髓炎豚鼠血浆PGE2、ACTH和皮质醇的水平变化  

A Study of PGE2,ACTH and Cortisol in Plasma in Experimental Allergic Encephalomyelitis in Guinea Pigs

作　　者：戚晓昆[1] 朱克[1] 张凤英[1] 刘洁晓[1] 

机构地区：[1]北京海军总医院神经内科

出　　处：《中国神经免疫学和神经病学杂志》1995年第2期74-78,共5页Chinese Journal of Neuroimmunology and Neurology

摘　　要：用放射免疫分析法测定ＥＡＥ豚鼠血浆ＰＧＥ２、ＡＣＴＨ和皮质醇的水平。结果发现发病重的动物血浆ＰＧＥ２水平显著低于正常和发病轻的动物，而发病轻的动物ＰＧＥ２水平略高于正常动物，但两者比较无统计学差异，提示ＰＧＥ２可能对神经系统炎性脱髓鞘病的发生和发展有调节作用。ＥＡＥ发病动物血浆ＡＣＴＨ和皮质醇的水平显著高于正常动物。发病重的动物ＡＣＴＨ水平高于发病轻的动物，但两者比较无统计学差异；而发病重的动物皮质醇水平显著高于发病轻的动物。血浆ＡＣＴＨ和皮质醇水平的增高，一方面是对应激的反应，另一方面可能是自身保护性的反馈调节。以上ＰＧＥ２、ＡＣＴＨ和皮质醇水平变化的研究，可能有助于对ＥＡＥ病情进一步做出判断和评价。The plasma levels of prostaglandin E2 ( PGE2 ) and adrenocorticotropin hormone (ACTH) and cortisol in experimental allergic encephalomyelitis in guinea pigs have been determined by method of radioimmune assay.PGE2 levels in severe-type EAE animals were significantly lower than those in both normal control group(NCG) and mild-type EAE, PGE2 may be important in regulating or controlling onset and development of demyelinating diseases.The plasma levels of ACTH and cortisol in EAE were significantly higher than those in NCG and the levels in severe-type animals were higher than those in mild-type ani mals.It might be a result of stress,on the other hand it might be protective feedback regula tion for organism..Perhaps we could estimate the states of EAE through the changing of these hormones.

关 键 词：ACTH PGE2 皮质醇 血浆 发病 EAE 正常 动物 水平 反馈调节 

分 类 号：R744[医药卫生—神经病学与精神病学] R285.5[医药卫生—临床医学]