阿司匹林对急性脑梗死患者血浆一氧化氮及血小板α颗粒膜蛋白的影响  

Effect of aspirin on plasma levels of nitric oxide and alpha-granule membrane protein in patients with acute cerebral infarction

作　　者：王丹[1] 朱浩佳[1] 梁焯辉[1] 王小朝[2] 

机构地区：[1]广东省江门市人民医院神经内科,529000 [2]广东省江门市人民医院检验科,529000

出　　处：《中国实用内科杂志》2004年第12期747-748,共2页Chinese Journal of Practical Internal Medicine

基　　金：广东省科委重点攻关项目 (0 0G0 0 2 0 1 63 )

摘　　要：目的　探讨阿司匹林对急性脑梗死患者血浆一氧化氮 (NO)及血小板α颗粒膜蛋白 (GMP 14 0 )的影响。方法　 2 0 0 2 - 0 5～ 2 0 0 3- 0 8广东江门市人民医院 78例急性脑梗死患者随机分为 4 0例治疗组和 38例对照组 ,采用硝酸酶还原法和双抗体夹心酶联免疫吸附法分别测定治疗组和对照组的血浆NO及GMP 14 0的含量。治疗组患者经过阿司匹林治疗后 2周 ,再次测定治疗组和对照组的血浆NO及GMP 14 0的含量。结果　治疗组治疗后患者血浆NO及GMP 14 0水平较对照组治疗后明显下降 (P <0 0 1) ,治疗组治疗后的ESS分值高于对照组治疗后的ESS分值 (P <0 0 1)。结论　阿司匹林能通过降低急性脑梗死患者血浆NO及GMP 14 0的水平 ,从而减轻缺血性脑损伤 ,起到脑保护作用。Objective To explore effect of aspirin on plasma levels of nitric oxide (NO) and alpha-granule membrane (GMP-140) protein in patients with acute cerebral infarction.Methods 78 patients with acute cerebral infarction were randomly divided into the aspirin group (40 cases) and the control group (38 cases).Plasma NO and GMP-140 were determined by the method of nitrate reductase and enzyme-linked immunosorbent assay in aspirin group and controls at moment of hospitalization and after two weeks.Results Plasma NO and GMP-140 of aspirin group after aspirin treatment were statistically lower than those of controls (P<0.01).ESS of aspirin group after treatment was higher than that of control group (P<0.01).Conclusion Aspirin can reduce plasma levels of NO and GMP-140 in patients with acute cerebral infarction.It can ameliorate brain injury after ischemia and has protective effect upon the ischemia cerebral tissue.

关 键 词：阿司匹林 急性脑梗死 一氧化氮 血小板 Α颗粒膜蛋白 缺血性脑损伤 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]