43例肠道淋巴瘤临床病理及TIA-1的表达  

The pathological changes and expressions of TIA-1in43cases of in testinal lymphoma

作　　者：任兴昌[1] 李甘地[2] 刘卫平[2] 张文燕[2] 李俸媛[2] 

机构地区：[1]杭州市中医院,310006 [2]四川大学华西医院,610041

出　　处：《浙江临床医学》2004年第12期1031-1032,共2页Zhejiang Clinical Medical Journal

基　　金：国家自然科学基金资助项目(39772001)

摘　　要：目的 探讨肠道淋巴瘤临床病理及TIA -1的表达。方法 观察24例肠道T细胞淋巴瘤 (ITCL)及19例肠道B细胞淋巴瘤(IBCL)的临床病理改变 ,免疫组织化学染色 ,选用抗体有UCHL-1、L26、CD3、KP-1、TIA -1等。结果 ITCL男女之比为3.8:1,发病中位年龄为28.5岁 ;IBCL分别为2.2:1及50岁。ITCL病人发生便血及明显发热 (65.2 % ,47.8% ) ,明显高于IBCL(22.2%,0% )。均未见确切乳糜泻病史。内镜、手术及大体观察 ,肠道多部位受累者ITCL明显多于IBCL(45.8%及15.8% )。ITCL82.6%为大小、深浅不一、多少不等、形状不规则的溃疡 ,34.8 %出现腹膜炎/肠穿孔 ;IBCL100 %表现为肠壁肿块或增厚。除1例小细胞型外ITCL均表达TIA -1,IBCL不表达TIA -1。结论 ITCL与IBCL不同的临床病理表现与瘤细胞是否表达TIA -1,可能与ITCL属细胞毒性T细胞或NK细胞淋巴瘤有关。Objective To explore the correlation between the clinic pat hological characteristics of intestinal lymphoma and the expressions of TIA-1. Methods The clinic pathological data of24cases of intestinal T-cell lymphoma(ITCL)and19cases of intestinal B-cell lymphoma(IBCL)were investigated,the antibodies UCHL-1,L26,CD3,KP-1,TIA-1were employed in immunohistochemical staining. Results The male to female ratios of ITCL and IBCL were3.8:1and2.2:1and with median age of28.5years and50years respectively.The incidence of symptoms such as hemaˉtochezia and fever in patients with ITCL(65.2%,47.8%)was higher than in patients with IBCL(22.2%,0%).Eight patients with ITCL had acute abdominal emergencies due to spontaneous perforation(34.8%).ITCLs frequently showed multiple ulcers in bowel and involved more in large bowel,whereas IBCLs were more present as mass or thickness of bowel wall.Histologically,the feature of ITCL were diffusive necrosis,angiocentric infiltration of neoplastic cells,and more eosinophils between neoplastic cells.Giant and weird tumour cells emerged in some IBCLs.TIA-1expression were present in tumor cells of ITCL except only one case of small cell type,but not in those of IBCL. Conclusion The clinic pathological and TIA-1expression difˉference between ITCL and IBCL might be the results of ITCL deriving from cytotoxic T-or NK cell.

关 键 词：ITCL TIA 表达 肠道淋巴瘤 临床病理 观察 瘤细胞 方法观 结论 大小 

分 类 号：R735.3[医药卫生—肿瘤]