乳腺原发恶性淋巴瘤的诊断及治疗方法探讨  

Diagnosis and treatment of primary breast lymphomas

作　　者：张玉晶[1] 夏云飞[1] 崔念基[1] 郑玮[2] 陈培松[2] 何溪[2] 

机构地区：[1]中山大学肿瘤防治中心,广东广州510060 [2]中山大学中山医学院

出　　处：《山东医药》2004年第36期11-12,共2页Shandong Medical Journal

摘　　要：目的　探讨乳腺原发恶性淋巴瘤(PBL)的临床特点及诊断、治疗方法。方法　对经病理检查证实的11例女性PBL患者的临床表现、检查及治疗方法、预后等进行分析。结果11例均经手术或穿刺活检取标本,组织学及免疫组织化学检查证实为非霍奇金氏淋巴瘤(NHL),B细胞来源10例、T细胞来源1例,弥漫性大B细胞型占54.5％(6／11)。10例分别接受乳腺肿瘤根治术或改良根治术或肿块切除术,均辅以化疗和放射治疗。首程治疗后7例获得局部控制,全组无病生存期4-49个月(中位生存期12个月),总生存期15-110个月(中位30个月)。结论PBL的确诊依靠病理组织学和免疫组织化学检查。治疗应包括局部手术、放射治疗和化疗的综合治疗。Objectives To study the clinical features,diagnosis,treatment outcome,and the prognosis of primary breast lymphoma (PEL). Methods 11 female patients with PBL were analysised in clinical features, diagnosis and treatment methods. Results All the PBL were pathologically confirmed as non-Hodgkin's lymphomas, 10 tumors were from B lymphocyte orgination,and 1 tumor was T lymphocyte origination. 54. 5% of the tumors were diffuse large B cell lymphoma. The treatment mainly included radical or modified radical mastectomy to lumpectomy, chemotherapy and radiotherapy. Tumor of 7 patients got local controlled after primary treatment. Disease free survival time of the whole group was 4-49 months (median 12 months), and overall survival time was 15- 110 months (median 30 months). Conclusions Diagnosis of PBL should adopt histological and immunohistochemistry examinations. Treatment of PBL should combine local resection, radiotherapy,and chemotherapy.

关 键 词：诊断 乳腺原发恶性淋巴瘤 治疗方法 免疫组织化学检查 B细胞 PBL 化疗 结论 目的 局部 

分 类 号：R737.9[医药卫生—肿瘤] R733[医药卫生—临床医学]