乳腺癌患者血清LEP、IGF-1和TNFα测定的临床意义  

Clinical significance of detection of serum leptin, insulin-like growth factor-1 and tumor necrosis factor α in breast cancer patients

作　　者：高菊兴[1] 张纪云[2] 董庆玉[1] 

机构地区：[1]临沂市人民医院,山东临沂276003 [2]临沂医学专科学校,山东临沂276002

出　　处：《检验医学》2005年第1期28-29,共2页Laboratory Medicine

摘　　要：目的　探讨乳腺癌患者血清瘦素(LEP)、胰岛素样生长因子 1(IGF 1)、肿瘤坏死因子α(TNFα)测定 的意义。方法　分别用放射免疫分析法(RIA)和免疫放射分析法(IRMA)测定乳腺良、恶性病变患者及正常对 照者血清LEP、IGF 1和TNFα浓度。结果　LEP、IGF 1和TNFα浓度在乳腺癌患者与正常对照组之间差异均有 显著性。结论　检测血清LEP、IGF 1、TNFα浓度,有助于判断乳腺癌的病变状态。Objective To explore the clinical significance in the detection of serum leptin(LEP), insulin-like growth factor-1(IGF-1) and tumor necrosis factor α(TNFα) in breast cancer patients. Methods Serum concentrations of LEP,IGF-1 and TNFα in breast cancer patients, breast benign lesion patients and normal controls were determined with RIA and IRMA methods. Results Serum concentrations of LEP,IGF-1 and TNFα in breast cancer patients were obviously different from that of normal control group. Conclusions The determination of the serum concentrations of LEP,IGF-1 and TNFα is useful for the judgement of the state of breast cancer patients.

关 键 词：IGF-1 TNFΑ LEP 乳腺癌 患者 血清 正常 显著性 病变 胰岛素样生长因子-1 

分 类 号：R737.9[医药卫生—肿瘤] R589.2[医药卫生—临床医学]