多功能转录因子CTCF研究进展  

Progress in research of transcription factor CTCF

作　　者：何莉[1] 朱旭东[1] 黄培堂[1] 

机构地区：[1]军事医学科学院生物工程研究所

出　　处：《生物技术通讯》2004年第6期600-603,共4页Letters in Biotechnology

摘　　要：CTCF是一种多功能的真核转录因子,它可以抑制c-myc基因的表达,增强app基因的启动子活性,调控H19/Igf2的印记,作为鸡β-球蛋白等多个基因结构域的绝缘子成分,以及作为X染色体失活的候选蛋白等。CTCF与BORIS的交互表达和雄性生殖细胞的系统发生有关。CTCF的缺失和突变可能导致肿瘤的发生。CTCF is a multivalent eukaryotic transcription factor. It involves in different aspects of gene regulation, such as repression, activation, silencing and insulation. It also participates in functional 'reading' of gene imprinting marks and X-inactivation. CTCF and BORIS are expressed in a mutually exclusive way in male germ line, participating in its epigenetics. Deletion and mutation of CTCF is associated with cancer.

关 键 词：肿瘤 表达 核转录因子 c—myc基因 APP基因 研究进展 突变 X染色体失活 系统发生 IGF2 

分 类 号：Q753[生物学—分子生物学] R749.16[医药卫生—神经病学与精神病学]