大鼠种植型肝癌电化学治疗的实验研究  

Experimental Study of Electrochemotherapy on Rats with Implanted Liver Tumor

作　　者：邵成伟[1] 王培军[1] 田建明[1] 张火俊[1] 左长京[1] 郝西彦[1] 任方远[1] 袁庆中[1] 李树平[1] 

机构地区：[1]第二军医大学长海医院放射科,上海200433

出　　处：《中国医学影像技术》2003年第6期659-661,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金资助课题 (30 0 70 2 33)

摘　　要：目的　探讨电化学疗法 (ECHT)对大鼠种植型肝癌的治疗效果。方法　制作大鼠肝癌动物模型 ,应用电化学疗法进行治疗 ,1周后影像学、病理光镜观察肿瘤大小、坏死、凋亡变化 ,与对照组比较 ,并观察生存期的长短。结果　电化学治疗前 ,大鼠肝肿瘤平均体积为 ( 10 0± 6)mm3 ,电化学治疗后 1周 ,大鼠肝肿瘤平均体积为 ( 12 5± 10 )mm3 ,而荷瘤对照组肝肿瘤平均体积为 ( 190± 11)mm3 ;治疗组肿瘤生长率为 2 5 % ,而荷瘤对照组肝肿瘤生长率为 90 % ,P <0 .0 5。治疗组病理光镜下肿瘤明显坏死 ,并可诱发细胞凋亡 ;生存期明显延长。结论　电化学疗法可明显抑制肿瘤生长 ,促进肿瘤坏死 ,诱发细胞凋亡 ,延长大鼠生存期。Objective To study the effects of ECHT on rats with implanted liver tumor. Methods Immediate cancerous ascite injection method was used to make rat liver tumor model, then rat liver tumors were treated with ECHT. Tumor size, necrosis and apotosis were observed one week after ECHT by imaging and pathology method. The results were compared with those of control group. The living times were observed also. Results Before ECHT,mean rat liver tumor volume was (100±6)mm 3.One week after ECHT,mean tumor volume in ECHT group (125±10)mm 3 was significantly smaller than that of control group (190±11)mm 3. Tumor growth rate in ECHT group (25%) was significantly lower than that of control group(90%), P <0.05. Necrosis, apotosis and survival time in ECHT group increased significantly than those of control group. Conclusion The growth of rat liver tumor is suppressed and the survival time is prolonged significantly by ECHT. [

关 键 词：大鼠 电化学治疗 肝癌 肝肿瘤 电化学疗法 对照组 鼠肝 理光 制作 延长 

分 类 号：R735[医药卫生—肿瘤] R730[医药卫生—临床医学]