血管性痴呆的智能测验与P_(300)的相关性研究  

The Correlative Study on Intelligence Test of Dementia And P_(300) of Vascular Dementia

作　　者：张宗逸[1] 张杰伦[1] 陈鹏亚[1] 王威[1] 刘学振 

机构地区：[1]哈尔滨市第一医院 [2]不详

出　　处：《黑龙江医学》1999年第12期1-2,共2页Heilongjiang Medical Journal

摘　　要：目的：事件相关电位（P300）是与人脑认知活动有关的脑电位变化，可评价信息加工过程脑功能状态与机理。方法：我们应用长谷川信彦痴呆量表测验27例血管性痴呆患者的智能，同时测验33例非痴呆患者的智能。结果：血管性痴呆组的智能得分明显低于非痴呆组。再分别检查两组患者的听觉事件相关电位，发现血管性痴呆组的P300潜伏期较非痴呆组明显延迟，提示P300潜伏期延迟可反映患者的智能障碍。另选智能测验得分由低至高的31例患者，观察其P300潜伏期的变化，发现智能测验得分与P300潜伏期至高度负相关。即智能测验得分越低，智能障碍越严重，P300潜伏期越延迟，说明P300潜伏期的长短可反映血管性痴呆患者痴呆的程度。结论：P300潜伏期可用于血管性痴呆患者的检查，并可反映其智能障碍的程度，是血管性痴呆较为客观可靠的检查指标。To discuss the relationship between the intelligence test and event related potential (P300) and observe the changes of P300 in vascular dementia patient. Methods: The intelligence tests were performed in 27 cases vasculardementia and 33 normal persons as control group. Other 31 vascular dementia patients were observed in latent periodchanges on P300. Results: The intelligence test score in test group were lower than control group obviously. The delayed latentperiod of P300 in test group was taken significantly. The more severe intelligence disorder, the more delayed latent period.Conclusion:The latent period of P300 could be used to detect vascular dementia and reflected the degree of inteiligence disorder so it may be a reliable index for vascular dementia.

关 键 词：P300 潜伏期 血管性痴呆患者 患者 智能障碍 智能测验 相关性研究 得分 评价信息 结论 

分 类 号：R749[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]