HGF/SF-Met signaling in tumor progression  

作　　者：George F. VANDE WOUDE 

机构地区：[1]Laboratory of Molecular Oncology, Van Andel Research Institute,#333 Bostwick Ave., N.E, Grand Rapids, MI 49503, USA

出　　处：《Cell Research》2005年第1期49-51,共3页细胞研究（英文版）

摘　　要：Tumor progression is a multi-step process that requires a sequential selection of specific malignant phenotypes. Met activation may induce different phenotypes depending on tumor stage: inducing proliferation and angiogenesis in pri- mary tumors, stimulating motility to form micrometastases, and regaining the proliferation phenotype to form overt metastases. To study how HGF/SF-induced proliferative phenotypes switch to the invasive phenotype is important for understanding the mechanism of tumor progression and will provide an attractive target for cancer intervention and therapy.

关 键 词：HGF/SF-Met SIGNALING tumor progression. 

分 类 号：R730.2[医药卫生—肿瘤]