食管癌手术切缘组织P^(53)基因突变的临床研究  

作　　者：高元兴[1] 董光同[1] 胡咏武[2] 胡正扬[1] 

机构地区：[1]温州医学院附属第一医院,325000 [2]温州医学院遗传教研室,325000

出　　处：《浙江临床医学》2005年第1期5-6,共2页Zhejiang Clinical Medical Journal

摘　　要：目的　 检测食管癌手术切缘组织P53基因突变 ,并对食管癌切除后的效果进行评价。 方法　 采用PCR -SSCP对 60例食管癌组织、切缘组织P53基因突变进行分析 (切缘病理切片无癌细胞残留 )。 结果　 60例原癌组织中有 2 8例 ( 4 5 % )切缘组织检测P53基因突变 ,切缘组织P53突变患者预后差 ,其肿瘤复发率 ( 5 4% ) ( 15 /2 8) ,而P53基因无突变者无 1例复发。两组复发率存在显著性差异 (P <0 .0 5 )。 结论　 检测切缘组织P53基因突变为“分子定界” 。Objective To evaluate the post-operative effect of esophageal cancer by detecting the P 53 gene mutation of esophageal cancer operative cutting edge tissues. Methods the P 53 gene mutations of 60 cases of esophageal cancer tissues and cutting edge tissues without the remaining carcinoma cell in the pathological section of cutting edge tissues were analyzed by PCR-SSCP. Results In 60 cases of proto-oncotissues, the cutting edge tissues of 28 cases(46.67%) were detected the P 53 gene mutation. The patients with the P 53 gene mutation of the cutting edge tissues had the bad prognosis and their carcinoma recurring rate is 53.57%(15/28). But none of the patients without the P 53 gene mutation had recurred. The recurring rate of the two groups has a significant difference(P<0.05). Conclusion Detecting the P 53 gene mutation of the cutting edge tissues could be the important way to judge the recurring of post-operative remaining.

关 键 词：P^53基因 切缘组织 突变 食管癌手术 切除后 复发 临床研究 结论 分子 显著性差异 

分 类 号：R735.1[医药卫生—肿瘤]