肝豆状核变性患者血清PCⅢ和TGF-β_1的测定及临床意义  

Clinical Significance of Determination of Serum Procollagen TypeⅢ(PCⅢ) and TransformingGrowth Factor Betal (TGF-β 1) Levels in Patients with Hepatolenticular Degeneration

作　　者：吴君霞[1] 林祥宏[1] 韩红波[1] 何志超[1] 许赣[1] 杨任民[1] 

机构地区：[1]安徽中医学院神经病学研究所附属医院检验科,230031

出　　处：《放射免疫学杂志》2005年第1期16-17,共2页Journal of Radioimmanology

摘　　要：目的:探讨肝豆状核变性(HLD)患者Ⅲ型前胶原(PCⅢ)和转化生长因子-β1(TGF-β1)的变化及 临床意义。方法:对112例HLD患者和30例正常对照组用放射免疫分析检测PCⅢ和用酶免法检测TGF-β1 的水平。结果:HLD组PCⅢ和TGF-β1的水平显著高于正常对照组(P<0.01)。结论:血清PCⅢ和TGF-β1 的测定可较好地反映肝纤维化的程度。Objective To investigate the clinical significance of the changes of serun procollagen typeⅢ (PCⅢ) and transforming growth factor betal (TGF-β 1) levels in patients with hepatolenticular degeneration (HLD). Methods Serum PCⅢ levels (with RIA) and TGF-β 1 levels (with ELISA) were determined in 112 patients with HLD and 30 controls. Results The levels of serum PCⅢ and TGF-β 1 in HLD patients were significantly higher than those in the controls (P<0.01). Conclusion Determination of serum PCⅢ and TGF-β 1 levels might be able to reflect the degree of hepatic fibrosis.

关 键 词：PCⅢ TGF-Β1 患者 HLD 肝豆状核变性 临床意义 血清 水平 转化生长因子-Β1 变化 

分 类 号：R575[医药卫生—消化系统] R742.4[医药卫生—内科学]