ADAS-Cog中文版区分轻、中度阿尔茨海默病的能力  

Discriminatory Potential of The Chinese version of ADAS-Cog for Mild versus Moderate Alzheimer Disease

作　　者：于欣[1] 王华丽[1] 李淑然[1] 陈玉芳[1] 李海东[1] 贺军[1] 

机构地区：[1]北京大学精神卫生研究所,100083

出　　处：《中国心理卫生杂志》2005年第1期31-33,共3页Chinese Mental Health Journal

基　　金：北京市科学技术委员会"十五"攻关协作研究项目"早期老年期痴呆临床应用量表规范化研究"子课题(编号:H010210550113)

摘　　要：目的:探讨阿尔茨海默病评定量表认知部分(ADAS-Cog)中文版区分轻、中度AD的能力。方法:199例轻度和106例中度AD患者为研究被试(符合NINCDS-ADRDA很可能AD诊断标准),对所有被试进行ADAS-Cog中文版测试。结果:中度AD患者ADAS-Cog总分及各条目评分明显高于轻度AD被试,GLM分析提示ADAS-Cog评分不受被试年龄与受教育程度的影响,ADAS-Cog能有效反映轻、中度AD患者不同的认知损害模式而不依赖于被试的学历。Logistic回归分析定向力和结构性练习条目评分及ADAS-Cog总分能有效区分轻、中度AD,敏感度为78%-82%,特异度为70%-73%。结论:ADAS-Cog中文版对轻、中度AD具有较好的区分能力,推荐将该量表用于评估药物对中国AD患者认知功能的疗效。Objective:To examine the discriminatory potential of the ADAS-Cog, Chinese version for mild and moderate Alzheimer's disease (AD). Methods:Patients with AD (199 mild AD and 106 moderate AD) meeting the NINCDS-ADRDA criteria of probable AD were recruited. The Chinese version of ADAS-Cog was administered to all AD subjects. Results:The total score of ADAS-Cog and the score of each ADAS-Cog item differed significant-ly between mild and moderate AD groups, with higher scores in moderate AD group. GLM analysis showed insignifi-cant influence of age or educational level on the ADAS-Cog total score. These results indicated that ADAS-Cog could represent the distinctive profiles of cognitive impairment between mild and moderate AD. The results of Logis-tic regression analysis showed that the item score of orientation and constructional praxis as well as the ADAS-Cog total score could classify mild and moderate AD efficiently, with a sensitivity of 78% - 82% and a specificity of 70% - 73%. Conclusion:Our results indicate that the Chinese version of ADAS-Cog is useful for staging of AD. It is recom-mended that the Chinese version of ADAS-Cog be introduced for monitoring the AD drug therapeutic efficacy on cognitive impairment among Chinese AD patients.psychiatry Alzheimer's disease

关 键 词：精神病学 阿尔茨海默病 心理测量学 中国人群认 知障碍 

分 类 号：R749.16[医药卫生—神经病学与精神病学]