硒的化学形式对人血中含硒组分的影响  

EFFECTS OF CHEMICAL FORMS OF Se ON Se CONTAINING COMPONENTS OF HUMAN BLOOD

作　　者：夏弈明[1] 赵新娥[1] 周燕[1] 朱莲珍[1] Philip D.Whanger 

机构地区：[1]中国预防医学科学院营养与食品卫生研究所,北京100050 [2]美国俄勒冈州立大学

出　　处：《营养学报》1993年第2期157-162,共6页Acta Nutrimenta Sinica

基　　金：国家<七五>关项目 75-62-03-03 (2)经费资助;美国NIH资助(R01DK38341)

摘　　要：在低膳食硒地区的农村,对健康男性受试者进行了为期一年的补硒干预试验。所有受试者每天服硒200μg,以硒酸钠或硒蛋氨酸形式供给。血样分析结果表明,这两种形式的硒均能有效地提高低硒人体的谷胱甘肽过氧化物酶(GPx)活力,因而在预防克山病工作中可采用较为经济的硒酸钠;但补硒蛋氨酸后可见“富裕”硒进入了红细胞的Hb和血浆的白蛋白中,而补硒酸钠后未见“富裕”硒,因而为提高人体硒营养水平,以补充硒蛋氨酸形式的硒为宜。Intervention study of Se supplementation for healthy male adults have been conducted at a village with low dietary Se intake for one year. All subjects took 200μg of Se per day in the form of selenate or selenomethionine. Analysis of blood samples showed that the two forms of Se had the same efficiency for Se incorporation into GPx. So inexpensive selenate could be used for the prevention of Keshan disease on a large scale. However, there was 'excess Se' entering Hb or albumin with selenomethionine, but no 'excess Se' with selenate. Therefore, it was appropriate to take Se in the form of selenomethionine for increasing the nutritional level of Sc in human body.

关 键 词：硒酸钠 硒 谷胱甘肽 过氧化物酶 

分 类 号：R151.3[医药卫生—营养与食品卫生学]