硒和血红蛋白关系的初探  

PRELIMINARY STUDY ON THE RELATION BETWEEN SELENIUM AND HEMOGLOBIN

作　　者：夏弈明[1] 周燕[1] 郑白羽[1] 哈鹏程[1] 朱莲珍[1] 

机构地区：[1]中国预防医学科学院营养与食品卫生研究所,北京100050

出　　处：《营养学报》1993年第3期261-264,共4页Acta Nutrimenta Sinica

基　　金：国家"七五"攻关项目75-62-03-03(2)经费资助

摘　　要：本文探讨了硒(Se)在血红蛋白(Hb)上的分布,以及摄硒量和摄硒形式对其分布的影响。结果表明,人体Hb中Se全部在珠蛋白上,且均匀分布于α和β链上;当硒蛋氨酸形式的硒摄入较多而在Hb中出现“富裕”硒时,在分离过程中有一部分硒会从Hb上脱落下来。这就提示Se与Hb之间至少存在紧密和松散的两种连接方式。 据α和β链中氨基酸的组成,我们推测,Se和Hb之间较紧密的连接是以硒蛋氨酸形式存在,它是膳食硒在Hb合成时掺入的;那松散的连接是有一部分“富裕”硒与半胱氨酸(CyS),特别是β链93位的CyS,连接形成不稳定的硒代三硫化物或硒过硫化物,它们在分离时很容易被还原脱落。一旦机体需要硒时,有可能首先动用这部分硒。The distributioa of Se in Hb and the effects of Se intake and its chemical forms oil the distribution were studied. The results showed that Se in human Hb was all located in globin and divided equally in a and β chains. However, a part of Se could fall from Hb during the process of isolation when more Se as SeMet was taken and 'excess' Se appeared in Hb. It was implicated that there were at least two kinds of linkage between Se and Hb --tight and loose.Regarding the components of amino acid in α and β chains, we assumed that a tight linkage between Se and Hb was in the form of SeMet, which was incorporated into Hb by dietary Se during the synthesis of Hb; the loose linkage was formed by a part of 'excess' Se and CyS, especially No.93 CyS in β chain, being unstable sclcnotrisulf ide or selenopersulfide, which broke easily by reduction during isolation. They might be utilized first by human body when Se was required.

关 键 词：硒 血红蛋白 珠蛋白 α链 Β链 

分 类 号：R151.2[医药卫生—营养与食品卫生学]