伴有8；21染色体易位和寡原始细胞白血病是骨髓增生异常综合征吗？  

Myelodysplastic syndromes with 8;21translocation:case report and reciew of the literature

作　　者：薛永权[1] 虞斐[1] 邹正辉[1] 过宇[1] 谢新 

机构地区：[1]江苏省血液研究所,苏州医学院第二附属医院血液科

出　　处：《中国优生与遗传杂志》1994年第F08期5-8,共4页Chinese Journal of Birth Health & Heredity

摘　　要：报道１例伴有ｔ（８；２１）易位、４号三体和寡原始细胞的白血病；初诊时患者有贫血和血小板减少，骨髓象显示１４％的原始细胞和涉及三系的病态造血改变，确诊为原始细胞过多的难治性贫血。骨髓中期细胞Ｇ和Ｒ带染色体分析揭示其核型为４６，ＸＸ，ｔ（８；２１）（ｑ２２；ｑ２２）／４７，ｉｄｅｍ，＋４／４６，ＸＸ。３个月后转化为Ｍ２型白血病，化疗未获完全缓解，最终死于败血症。结合文献中的１０例伴有ｔ（８；２１）易位和寡原始细胞的白血病。对其临床和生物学意义作了简要讨论，指出该类疾病的临床和生物学特性更象原发性急性非淋巴细胞白血病而非真正的骨髓增生异常综合征，故应尽早给予强烈化疗。An 8:21 translocation with trisomy 4 and oligoblasts is described in a patient with leukemia,She had anemia and thrombocytopenia at presentation. Bone marrow aspirate showed 14% blasts and dysplastic changes involving trilineage.She was diagnosed as having refractory anemia with excess blasts.Chromosome analysis of marrow metaphases whth R and G bands revealed its karyotype to be as follows:46,XX,t(8;21)* in the literature, we discuss concisely its clinical and biological significance :It behave much like de novo ANLL. Thus,it is not a true myelodysplastic syndrome and such cases should be treated without delay with intensive chemotherapy.

关 键 词：原始细胞 白血病 骨髓增生异常综合征 临床 化疗 染色体易位 难治性贫血 生物学意义 核型 转化 

分 类 号：R733[医药卫生—肿瘤] R551.3[医药卫生—临床医学]