人体正常卵巢和卵巢恶性肿瘤雌激素及孕激素受体5年研究总结  

Estrogen and Progesterone Receptors in Human Ovary and Ovarian Malignant Tumors

作　　者：韩守威[1] 彭芝兰[1] 何斌[1] 刘珊玲[1] 营泽毅 

机构地区：[1]华西医科大学附二院妇产科,成都市610041

出　　处：《中国肿瘤临床》1993年第12期891-893,共3页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助课题

摘　　要：用葡聚糖—活性炭单点饱和分析法测定261例正常卵巢组织,148例卵巢恶性肿瘤组织胞浆雌激素受体和孕激素受体(ER.PR)。结果表明,正常卵巢组织ER和PR均值和阳性率均高于恶性卵巢肿瘤组织。卵巢恶性病变中,性腺间质类ER和PR含量均高于上皮性肿瘤.生殖细胞源性肿瘤和转移性癌。上皮性恶性肿瘤中,内膜样癌的ER和PR含量高于浆液性,粘液性及透明细胞癌。提示受体含量高者有用内分泌治疗的可能和推测有转好的预后。卵巢恶性肿瘤患者临床分期及月经状况与其ER阳性率有关,而与PR阳性率无关。Ovarian specimens from 409 patients were assayed for estrogen and progesterone receptor (ER and PR)levels by Dextran-coated Charcoal method. The results indicated that the contents and positive rates of ER and PR in normal ovary were higher than that in ovarian malignancies. Among the malignant ovarian tumor, the mean ER and PR concentrations in sex-cord stromal tumors and endometrioid carcinomas were higher than in other malignant ovarian tumors (P<0. 001 ,P<0. 001). This suggested that the endocrine therapy are indicated for those patients with higher ER and PR concentration. The positivity rate and level of ER in malignant ovarian tumors was closely related to menstrual cycle of the patient as well as the clinical stage of the tumors, whereas that of.PR did not.

关 键 词：卵巢肿瘤 雌激素 孕激素 受体 癌 

分 类 号：R737.310.3[医药卫生—肿瘤]