小量阿斯匹林防治老年人缺血性脑血管病适宜剂量的研究  

Optimal Dosage for Low Dose ASA Prevention and Treatment in Geriatric Patients with Ischemic Cerebrovascular Disease

作　　者：马志忠[1] 罗毅[1] 汤洪川[1] 崔志锋[1] 李次芬[2] 殷宗健[2] 蔡乾铭 陈秀兰[3] 汪晓燕[3] 王红[3] 李晖[4] 

机构地区：[1]军医进修学院南楼临床部三科 [2]军医进修学院血液病化验室 [3]军医进修学院临床药学研究室 [4]军医进修学院医学统计研究室

出　　处：《军医进修学院学报》1993年第1期9-13,共5页Academic Journal of Pla Postgraduate Medical School

摘　　要：本文报道了用小量阿斯匹林(Acetylsalicylic Acid ASA)防治老年人缺血性脑血管病108例,按每日100毫克、50毫克、25毫克分三组每组各36例。各组皆取得了满意的治疗效果,而以50毫克组效果最佳。动态观察了64例血小板聚集力的变化。对其中22名正常人监测结果提示一次用药300毫克或100毫克对血小板聚集力的抑制作用可达7天之久,提示临床可应用比100毫克更小的剂量。另外对上述三组各14例的监测结果提示服药后血小板聚集力同样获得了满意的抑制效果,而抑制程度以50毫克组为佳。故我们提出小量ASA防治老年人缺血性脑血管病的适宜剂量为每日50毫克。108 geriatric patients with ischemic cerebrovascular diseases were treated with low dose aspirin(Acetylsalicylic acid, ASA). Daily doses of 100 mg, 50 mg and 25 mg were administered respectively to three groups of 36 patients each. All the groups showed satisfactory results, with the best in the 50 mg group. Changes in platelet aggregation responses were dyna- mically observed in 64 cases. Monitoring of 22 normal subjects revealed that inhibition on platelet aggregation with a dose of 300 mg or 100 mg could last as long as 7 days. This suggests that, clinically, doses of 100 mg or less can be used effectively. Satisfactory inhibitive effects on platelet aggregation were observed in all the three groups with 14 patients each given dally doses of 100 mg, 50 mg and 25 mg in the four weeks of observation after ingestion of the drug, with the most desirable degree of inhibition achieved in the 50 mg group. Therefore, We recommend 50 mg/d as the optimal dosage for low dose aspirin therapy in geriatric iscbemic cerebrovascular patients.

关 键 词：阿司匹林 早期 预防 脑缺血 老年人 

分 类 号：R743.305[医药卫生—神经病学与精神病学]