实验性大肠癌淋巴结转移过程的冷冻割断扫描电镜观察  

SCANNINC ELETRON MICROSCOPICAL OBSERVATION ON EXPERIMENTAL LYMPH NODE METASTASIS OF COLORECTAL CARCINOMA IN RATS BY FREEZE-CRACK TECHNIQUE

作　　者：黄卓垣 张亚历 候双凤 

机构地区：[1]第一军医大学病理解剖教研室,广州510515

出　　处：《癌症》1993年第4期282-283,287,T000,共4页Chinese Journal of Cancer

摘　　要：作者对二甲肼诱发的大鼠大肠癌自发性淋巴结转移模型首次用冷冻割断技术进行研究,探讨大肠癌淋巴结转移过程及其与血道转移的关系。结果表明:冷冻割断电镜技术较易观察癌细胞与血管的关系,大肠癌向淋巴结转移时,首先出现于被膜下窦,并在淋巴窦形成癌栓向周围组织浸润,而且淋巴结转移灶内存在瘤细胞淋巴与血道转移的双重途径,其中毛细血管后微静脉可能起着重要作用。Experimental lymph node metastasis of large bowel carcinoma induced with DMH in rats were studied by freez-crack scanning electron microscopy. The results showed that tumor ceDs firstly appeared in subcapsular sinus, formed cancer embolus which bbcked the lymphatic sinus and invased into tissue, and then deve loped metastatic tumor. Two metastatic mechanisms by lymphogenic or hematogenic routes were found. The significance of epitheloid venule had been discussed. It is suggested that freeze-crack technique are suitable to investigate the metastatic mechanisms of cancer cells by lymph and blood vessels.

关 键 词：大肠肿瘤 冷冻割断 扫描电镜 

分 类 号：R735.34[医药卫生—肿瘤]