取代嘧啶酮类抗病毒药物的研究──Ⅲ．嘧啶酮衍生物诱导血清及组织干扰素活性实验  

ANTIVIRAL ACTIVITY STUDY OF PYRIMIDINONE──Ⅲ. INTERFERON-INDUCING ACTIVITY EXPERIMENT

作　　者：刘新泳[1] 徐丽君 伊林[1] 乔文本 

机构地区：[1]山东省血液中心

出　　处：《山东医科大学学报》1994年第3期256-258,共3页Acta Academiae Medicinae Shandong

摘　　要：设计合成了１５个取代嘧啶酮衍生物，进行了诱导小鼠血清和组织器官干扰素的活性实验。结果表明，ＡＢＰＰ和ＡＢＭＰ是活性很强的干扰素诱导剂，而相对应的取代嘧啶硫酮化合物ＡＢＰＰＴ和ＡＢＭＰＴ则诱导活性降低；２位氨基是活性必需基因，２位肼基则无效；化合物６－对磺酸笨嘧啶酮类化合物水溶性强，诱导干扰素能力低；其它化合物血清和组织中诱导干扰素能力均不及ＡＢＰＰ和ＡＢＭＰ。A seris of newly-synthesized substituted pyrimidinone and substituted pyrimidine-thione derivatives had been tested for inducing mice serum and organ interferon when administered parenterally.The results showed that both ABPP and ABMP were high potential interferon- inducing agents,but the corresponding substituted pyrimidine-thions ABPPT and ABMPT were less active inducer; 2 -hydrazine substituted pyrinidinone was no activity.The derivatives of 6-sulfophenyl pyrimidinones were soluble in water,but interferon-inducing activity was less than ABPP.

关 键 词：嘧啶酮 嘧啶硫酮 干扰素诱导剂 

分 类 号：R978.7[医药卫生—药品]