十三碳二元酸发酵过程产酸期拟均相动力学模型及其应用  

The Pseudohomogeneous Kinetic Models of Production Phase in the Fermentation Process for Producing Undecane Dicarboxylic Acid and Their Application

作　　者：李元广[1] 曹竹安[1] 袁乃驹[1] 侯治中 

机构地区：[1]清华大学化学工程系

出　　处：《生物工程学报》1994年第4期318-325,共8页Chinese Journal of Biotechnology

基　　金：中国石化总公司自然科学基金;国家自然科学基金

摘　　要：分析了十三碳二元酸发酵过程中产酸期的代谢特点,对产酸期四相体系发酵动力学进行了研究。提出了菌体生长、产物形成及底物消耗的动力学模型,对模型参数进行了回归估值,并对产酸期进行了拟合,结果表明,模型的计算值和实测值较为吻合,平均相对偏差为3.6％。利用所建模型对产酸期进行了多种操作条件下的模拟计算,结果表明,提高进入产酸期的菌体浓度、缩短菌体生长期时间及降低发酵液中产物浓度具有提高产物形成速率的有效途径。The metabolic characters of production phase in the fermentation of unde-cane dicarboxylic acid were analyzed. The kinetic models of cell growth, product formation and substrate consumption in production phase were established respectively. The parameters of the models have been estimated by regression. The calculated curves fit the experimental date quite well and the average deviation between those over production phase is 3. 6%. Based on the kinetic models, computer simulations of production phase were fulfilled. From the computer simulations, it can be seen that the product formation rate could be increased markedly by the following ways: increasing cell concentration before switching into production phase, decreasing the peroid of cell growth phase and lowering the product concentration of production phase.

关 键 词：石油发酵 十三碳二元酸 发酵动力学 

分 类 号：TQ920.1[轻工技术与工程—发酵工程] Q81[生物学—生物工程]