焦脱镁叶绿酸的Knoevenagel反应及其杂环取代衍生物的合成  

Knoevenagel Reaction of Pyropheophorbide and Synthesis of Its Heterocyclo-substituted Derivatives

作　　者：王进军[1] 邬旭然[1] 韩光范[2] 沈荣基[3] 

机构地区：[1]烟台大学应用化学系,烟台264005 [2]江苏科技大学,镇江212003 [3]仁济大学微工程学院

出　　处：《有机化学》2005年第3期313-318,共6页Chinese Journal of Organic Chemistry

基　　金：科技部中韩政府间合作(No.2002)资助项目.

摘　　要：以焦脱镁叶绿酸-d甲酯(MPPd)为起始原料,通过其醛基与连有五元杂环的β-二酮、α-氰基酮和丙二腈的活性亚甲基进行Knoevenagel反应,完成3-位五元杂环取代的焦脱镁叶绿酸-a甲酯衍生物.所合成的新化合物均经UV,IR,H1NMR及元素分析证明其结构.Methyl pyropheophorbide-d was used as starting material and the Knoevenagel reaction of the aldehyde group on pyropheophorbide with active methylene group in,beta-diketone, alpha-cyanoketone or malononitrile was carried out to complete the synthesis of derivatives of methyl pyropheophorbide-a substituted with five-membered heterocycle at 3-positipon. The structures of all these new compounds were characterized by elemental analysis, UV, IR and H-1 NMR spectra.

关 键 词：杂环 取代 甲酯 起始原料 合成 衍生物 KNOEVENAGEL反应 Β-二酮 亚甲基 丙二腈 

分 类 号：O621[理学—有机化学]