电喷雾质谱新方法及在生命分析化学中的应用  

Novel approaches of electrospray ionization mass spectrometry and their application in the field of bio-analytical chemistry

作　　者：罗国安[1] 梁琼麟[1] 王义明[1] 曲峻[1] 

机构地区：[1]清华大学分析中心,北京100084

出　　处：《现代仪器》2005年第1期5-7,4,共4页Modern Instruments

基　　金：国家 973项目 ( 2 0 0 1CB5 10 3 0 6);科技部十五攻关项目 ( 2 0 0 4BA72 1AB)资助

摘　　要：电喷雾质谱是目前应用最广泛的生物质谱技术之一。复杂生物基质对质谱分析的选择性和准确性提出挑战 ,迫切需要在质谱方法学上有所发展。本文介绍具有广泛应用前景的几种电喷雾质谱新方法的原理和特点及若干应用实例 。The electrospray ionization mass spectrometry(ESI MS)was one of the most widely applicable bio-MS technologies.The complexity of biological matrices challenged the selectivity and accuracy of MS analysis,and demanded the development of MS methodology.Therefore several novel approaches based on ESI MS,which had a wide potential,were introduced with respect to their principle and merits as well as real examples in application.The trend of bio-MS technology and its future application in the field of bio-analytical chemistry were prospected.

关 键 词：电喷雾质谱 新方法 生命 质谱分析 准确性 挑战 分析化学 谱方法 选择性 应用实例 

分 类 号：TH122[机械工程—机械设计及理论] O65[理学—分析化学]