A Novel 5-Fluorouracil Salt of 12-Silicatungstic Acid: Synthesis,Structure Characterization and Antitumor Activity  

作　　者：LIJuan WUXin-yu LIJing WANGHong-fang QIYan-fei YUXi-he SUNZhi-wei WANGEn-bo 

机构地区：[1]DepartmentofHygienicChemistry,SchoolofPublicHealth,JilinUniversity,Changchun130021,P.R.China [2]InstituteofPolyoxometalateChemistry,FacultyofChemistry,NortheastNormalUniversity,Changchun130024,P.R.China

出　　处：《Chemical Research in Chinese Universities》2005年第2期127-130,共4页高等学校化学研究（英文版）

基　　金：SpportedbytheNationalNaturalScienceFoundationofChina(No.20171010).

摘　　要：A novel 5-fluorouracil salt of 12-silicatungstic acid was synthesized and characterized by means of elemental analysis, IR, 1H NMR and 183W NMR spectra. The antitumor activity and toxicity of the complex have been evaluated both in vitro and in vivo.A novel 5-fluorouracil salt of 12-silicatungstic acid was synthesized and characterized by means of elemental analysis, IR, 1H NMR and 183W NMR spectra. The antitumor activity and toxicity of the complex have been evaluated both in vitro and in vivo.

关 键 词：POLYOXOTUNGSTATE 5-FU Antitumor activity TOXICITY 

分 类 号：R979.1[医药卫生—药品] R917[医药卫生—药学]