6-乙酰氨基-1,2,3,4-四氢-1-萘酮的合成  

Synthesis of 6-acetamido-1-tetralone

作　　者：杨彦辉[1] 王庆河[1] 熊绪琼[1] 魏清 程卯生[1] 

机构地区：[1]沈阳药科大学制药工程学院,沈阳110016 [2]辽宁先臻制药有限公司,鞍山11401

出　　处：《中国新药杂志》2005年第2期177-178,共2页Chinese Journal of New Drugs

摘　　要：目的:合成中间体6-乙酰氨基-1,2,3,4-四氢-1-萘酮。方法:以苯甲酰基丙酸为原料,经过硝化、硝基还原、酰化、羰基还原、环合得到6-乙酰氨基-1,2,3,4-四氢-1-萘酮。结果与结论:只需经过5步反应就可以合成目标化合物,总收率14.7%。Objective: To synthesize 6-acetamido-1-tetralone, an intermediate of drug substances. Methods: Starting from 3-benzoylpropoinic acid, the target compound was prepared via nitrofication, nitro-reduction, acylation, carbonyl reduction and cyclization. Results: The total yield of the target compound was 14.7%. Conclusion: The synthetic route was easily manipulated.

关 键 词：6-乙酰氨基-1 2 3 4-四氢-1-萘酮 中间体 合成 

分 类 号：R9145[医药卫生—药物化学]