孕早期母血清筛查唐氏综合征  

Screening of Maternal Serum for Fetal Down's Syndrome in the First Trimester

作　　者：徐悦凡[1] 陈叙[1] 任晨春[1] 李金春[2] 魏振河[1] 张海霞[1] 张长俊[2] 王文靖[1] 刘国川[1] 郎玉萍[1] 李彬[1] 

机构地区：[1]天津市中心妇产科医院,300052 [2]天津市妇女保健所

出　　处：《天津医药》2005年第3期139-141,共3页Tianjin Medical Journal

基　　金：天津市自然科学基金资助项目(项目编号:023612511)

摘　　要：目的:用母血清生化标志物产前筛查唐氏综合征(DS).方法:用时间分辨免疫荧光分析法测定孕7～13周孕妇血清中妊娠相关血浆蛋白A(PAPP-A)和游离β-人绒毛膜促性腺激素(free β-HCG)的中位数,以及胎儿颈部透明膜厚度(NT)以确定高危人群,用T1-risk风险统计软件进行风险率计算,以1:250作为高风险的切割值,并通过绒毛染色体核型分析给予确诊.结果:359例孕妇中筛出高危个体40例,阳性率11.14%,确诊DS胎儿1例.计算出7～13孕周PAPP-A和free β-HCG中位数值.结论:在孕早期用检测PAPp-A和free p-HCG结合NT筛查DS胎儿,有望使产前诊断时间提前.Objective Maternal serum biochemical markers were used to screen for fetal down's syndrome DS in first trimester. Methods Time-resolved immunofluorometric assay TrIFMA was used for the concentration of PAPP-A and free-β-HCG in maternal serum at 7-13 gestational week internal in order to determine the high risk persons. The risk rate was calculated with T1-risk statistical software. 1∶ 250 was regarded as the cut-off value of high risk. The fetal karotype was identified by CVS. Results In 359 pregnant women 40 samples were screened of high risk. And one was identified as DS fetus. The positive rate was 11.14%. The Medians concentration of PAPP-A and free-β-HCG at 7-13 gestational week internal was also calculated. Conclusion Screening for Down's syndrome in the first trimester is feasible and the screening time would be earlier than before.

关 键 词：唐氏综合征 筛查 胎儿 PAPP-A 母血清 孕早期 Β-HCG 中位数 结论 行风 

分 类 号：R714[医药卫生—妇产科学] G633[医药卫生—临床医学]