端粒酶HTRT在鼻咽癌及癌前病变中的表达  

A study on the expression of HTRT gene in the tissues of nasopharyngeal carcinoma and precancerous lesion in the nasopharynx

作　　者：宋建新[1] 

机构地区：[1]浙江省台州市中心医院耳鼻咽喉科,318000

出　　处：《中国中西医结合耳鼻咽喉科杂志》2005年第1期4-5,共2页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的 观察端粒酶HTRT在鼻咽癌及癌前病变中的表达,探讨其在鼻咽上皮癌变中的可能作用。方法 运用免疫组化(LSAB)法检测端粒酶HTRT在正常鼻咽黏膜、鼻咽黏膜异型增生和鼻咽癌组织中的表达。结果 鼻咽正常黏膜全部为阴性,异型增生鼻咽组织阳性表达率较低,而鼻咽癌组织HTRT阳性表达率明显升高,但其表达与肿瘤分化程度、临床分型及淋巴结转移不相关。结论 HTRT表达在鼻咽癌发生中起一定作用。Objective To investigate the expressive activity of human telomerase reverse transcriptase (HTRT)gene in the tissues of nasopharyngeal carcinoma (NPC) and precanccrous lesion in the nasopharynx to explore its possible role in the carcinogenesis of nasopharyngeal epithelia. Methods Immunohistochemical assay (LSAB procedure) was used to determine the expressive activity of HTRT protein in the tissues of normal nasopharyngeal mucosa, dysplasia nasopharyngeal mucosa and NPC. Results Negative expression of HTRT protein was seen in normal nasopharyngeal mucosa,while lower positive rate of expression of it was determined in the nasopharyngeal mucosa with dysplasia. In contrast, highly elevated expressive rate of HTRT protein was found in the tissue samples of NPC,but with no significant correlation of this activity with histological grading,clinical staging and lymph node metastasis. Conclusion The expression of HTRT gene may play an ymportant role in the carcinogenesis of nasopharyngeal epithelia.

关 键 词：HTRT 阳性表达率 鼻咽癌组织 黏膜 端粒酶 癌前病变 正常 癌变 

分 类 号：R739.63[医药卫生—肿瘤]