高血压脑出血病人脑脊液sICAM-1与sIL-6R的对比观察  

The Comparison of sICAM-1 and sIL-6R in Soluble Intercellular Adhesion Molecule of Cerebrospinal Fluid from the Patients with Hypertensive Cerebral Hemorrhage

作　　者：李介华[1] 徐国祥[2] 冯建容[2] 

机构地区：[1]广东省清远市暨南大学医学院第五附属医院 [2]广东省清远市人民医院

出　　处：《中西医结合心脑血管病杂志》2005年第3期212-214,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：广东省医学科研基金项目 (No .A2 0 0 0 80 8) ;清远市医学科研计划资助项目 (No.2 0 0 0 1 3) 获 2 0 0 4年科技进步二等奖

摘　　要：目的对比观察高血压脑出血急性期不同时间脑脊液 (CSF)可溶性细胞间黏附分子 (sICAM -1)和可溶性白细胞介素 6受体(sIL -6R)及白细胞介素 6(IL -6)的变化与继发性脑损伤的关系。方法　采用酶联免疫吸附试验(ELISA)测定 2 0例 (对照组 )和 15例高血压脑出血病人CSF中sICAM -1、sIL -6R、IL -6含量变化。结果　高血压脑出血后第 1天CSFsICAM -1、sIL -6R、IL -6含量升高已达高峰。sICAM -1在出血后 5d～ 7d明显下降 ,但仍高于正常对照 ,而sIL -6R和IL -6虽有下降 ,但仍维持在较高水平 ,两者之间呈正相关 (P <0 .0 0 1) ,而sICAM -1与sIL -6R含量变化无明显相关 (P >0 .0 5 )。结论　sICAM -1、sIL -6R和IL -6参与高血压脑出血的免疫和炎症反应过程 ,与继发性脑损伤程度有关 ,sICAM -1与sIL -6R和ILObjective To observe the relation between the variance of soluble Intercellular Adhesion Molecule-1(sICAM-1) , soluble Inferleukin-6 Receptor(sIL-6R ) and Inferleukin-6( IL-6) in the cerebrospinal fluid of acute hypertensive cerebral hemorrhage with secondary brain injure. Methods Determine the change of sICAM-1,sIL-6R and IL-6 in the group (15 cases) of hypertensive cerebral hemorrhage and in control group(20 cases) by enzyme linked immunesorbent assay(ELISA).Results sICAM-1,sIL-6R and IL-6 were at peak in the first day in Cerebrospinal fluid (CSF) of hypertensive cerebral hemorrhage. sICAM-1 dramatically dropped in 5-7 day, yet kept higher than normal. sIL-6R and IL-6 dropped, but kept in a high level , there was positive correlation between them(r=0.773 8,P<0.001),but sICAM-1and sIL-6R were not related.(r=-0.114 1,P>0.05).Conclusion sICAM-1, sIL-6R and IL-6 were cooperated in the immunology and inflammatory in hypertensive cerebral hemorrhage and had the relationship with secondary brain injure. There may have difference in the regulatory mechanism of sICAM-1,sIL-6R and IL-6.

关 键 词：高血压脑出血 脑脊液 可溶性细胞间黏附分子 可溶性白 细胞介素6受体 

分 类 号：R743.3[医药卫生—神经病学与精神病学]