蛋白质转导技术及其应用  

Protein Transduction Technology and Its Applications

作　　者：陶站华[1] 王淑静[1] 刘兴汉[1] 

机构地区：[1]哈尔滨医科大学生物化学与分子生物学教研室黑龙江省生物医药工程重点实验室-省部共建国家重点实验室培育基地,哈尔滨市150086

出　　处：《医学分子生物学杂志》2005年第2期119-122,共4页Journal of Medical Molecular Biology

摘　　要：蛋白质转导结构域(protein transduction domain,PTD)是指一类能将其他生物大分子导入多种哺乳动物细胞的小分子阳离子多肽,它可以用于研究细胞内某些蛋白质的功能,还可以与具有治疗作用的蛋白质、多肽等生物大分子偶联,在缺血、肿瘤等多种疾病的治疗中有潜在的应用价值。The term 'protein transduction domain' (PTD) is typically used to refer to a class of small (<20 amino acid) cationic peptides that can transport large, biologically-active molecules into a population of mammalian cells, which serves as a useful tool in the study on protein functions. They are also of great value in the treatment of a variety of diseases, such as ischemia, neoplasm etc., when linked to therapeutical biologically-active molecules (such as polypeptides or proteins).

关 键 词：肿瘤 治疗中 多肽 缺血 治疗作用 细胞内 蛋白质转导结构域 生物大分子 哺乳动物细胞 PTD 

分 类 号：R730.54[医药卫生—肿瘤] Q7[医药卫生—临床医学]