吡唑烷酮类化合物的抗惊厥作用  

STUDIES ON THE ANTICONVULSIVE ACTIVITY OF PYRAZOLIDINONES

作　　者：刘菊芳[1] 裴印权[1] 王振东[1] 徐建国[1] 雷小平[1] 凌仰之[1] 

机构地区：[1]北京医科大学药理教研室,成都卫校药理教研室,乌鲁木齐市医院制剂室,北京医科大学药化教研室

出　　处：《药学学报》1994年第3期166-170,共5页Acta Pharmaceutica Sinica

基　　金：国家医药管理局和中国自然科学基金

摘　　要：对３类１４种吡唑烷酮类化合物的抗惊厥作用进行了比较研究，它们对最大电休克惊厥均有对抗作用，作用出现快，但维持时间较短，其中ＩＩ－ｆ作用最强，对听源性发作和家兔海马注射硫酸锌形成的慢性癫痫模型也有效。此外，ＩＩＩ－类尚能对抗戊四唑引起的阵挛性惊厥。The anticonvulsive activity of three kinds of pyrazolidinones:5-benzyl- substitut-ed-3-pyrazolidinones;5-benzyl-1-alkyl substituted and 1-alkyl substituted-3-pyrazolidinones werestudied. Fourteen substitutes of these three kinds of pyrazolidinones were found to be potent anticonvul-sants.In doses less than TD50,they were found tO be able to protect mice and rats from seizuresproduced by maximal electroshock seizure(MES),such action appeared rapidly and lasted for a shortperiod。II-f was shown to be the most potent anti-MES agent among these three kinds of pyrazolidi-nones.It also showed therapeutic effect in treating experimental epilepsy produced by intrahippocam-pal injection of zinc sulfate in rabbits and audiogenic seizures in rats.The third kind of pyrazolidinonesa1so showed anti-metrazol induced seizures in mice.

关 键 词：吡唑烷酮类 抗惊厥药 药理学 

分 类 号：R971.6[医药卫生—药品]