新生儿血清前白蛋白和氨基酸作为蛋白质营养指标的探讨  

BLOOD AMINO ACID AND PREALBUMIN AS PARAMETERS IN THE ASSESSMENT OFPROTEIN NUTRITION STATUS IN NEONATES

作　　者：周进[1] 朱慧芬[1] 徐惠君[1] 李玉忠[1] 满洪升[1] 濮良忠[1] 

机构地区：[1]大连医学院附属一院儿科,大连医学院分析测试中心

出　　处：《营养学报》1994年第1期67-72,共6页Acta Nutrimenta Sinica

基　　金：研究生经费及辽宁省教委重点课题

摘　　要：测定新生儿脐血、外周静脉血血清前白蛋白（ＰＡ）和２０种游离氨基酸（ＦＡＡ）。结果表明，小于胎龄儿（ＳＧＡ）血ＰＡ和几种氨基酸水平较适于胎龄儿（ＡＧＡ）显著降低，其氨基酸比率出现类似蛋白一能量营养不良者的氨基酸图谱。适于胎龄新生儿外周静脉血ＰＡ含量和大多数ＦＡＡ含量较脐血低，部分非必需氨基酸（ＮＥＡＡ）高于脐血。脐血与外周静脉血ＰＡ与总必需氨基酸／总氨基酸（ＴＥＡＡ／ＴＡＡ）比率均存在直线相关。结果提示：脐血或外周静脉血血清ＰＡ和ＦＡＡ同时测定可能作为评估新生儿宫内或宫外蛋白质营养状况的敏感生化指标。he umbilical and peripheral blood serum prealbumin (PA) level and concentrations of 20 free amino acids (FAA)were determined in term neonates.SGA infants had significantly lower concentration of PA,sum of BC-AA,4 EAA and 2 NEAA compared with those of AGA infants.The va-lues of AA ratios in SGA infants were similar to those found in protein一energy malnutrition. Thirty AGA infants had significantly lower concentration of PA andsome kinds of EAA and significantly higher levels of some kind of NEAA inperipheral blood serum as compared with those of cord serum in 44 AGA infants.There was singnificant correlation between PA and TEAA/TAA ratio both in cord and peripheral blood serum. Cord or peripheral blood serum PA and AA might be used as sensitivebiochemical markers to assess intrauterine or extrauterine nutritional statusof neonates.

关 键 词：新生儿 氨基酸 前白蛋白 

分 类 号：R151.2[医药卫生—营养与食品卫生学]