他克林及其衍生物的合成与表征  

Syntheses and Characterizations of Tacrine and Its Derivatives

作　　者：李加荣[1] 韩方斌[1] 杨新华[1] 李文婷[1] 马淑玲[1] 

机构地区：[1]北京理工大学化工与环境学院新医药研发中心,北京100081

出　　处：《合成化学》2005年第2期160-162,共3页Chinese Journal of Synthetic Chemistry

摘　　要：以廉价的靛红为起始原料,经靛红-3-肟和邻氨基苯甲腈两个中间体合成了他克林,并对其进行衍生化合成。所有新化合物的结构均经1HNMR,IR,MS和元素分析确证。Tacrine was prepared from the condensation of cyclohexanone with 2-cyanoaniline which was made from the industrial isatin. Some of tacrine derivatives were synthesized. Their structures were confirmed by 1H NMR, IR, MS and elemental analysis.

关 键 词：老年痴呆症 他克林 衍生物 合成 

分 类 号：R914[医药卫生—药物化学] O626[医药卫生—药学]