解毒酶GSTM1和GSTT1缺失与广西肝细胞癌相关性研究  被引量:2

Genetic Deletion of GSTM1 and GSTT1 Detoxicated Enzymes in Relation to Hepatocellular Carcinoma in Guangxi

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作  者:邓卓霖[1] 韦义萍[2] 马韵[1] 

机构地区:[1]广西医科大学病理学教研室,广西南宁530021 [2]广西医科大学护理学院病理学教研室,广西南宁530021

出  处:《广西科学》2005年第1期55-57,共3页Guangxi Sciences

基  金:国家自然科学基金 (3 9860 0 3 2 );广西教育厅重点资助课题基金(98-2 -8)资助项目

摘  要:为了研究谷胱甘肽硫转移酶 GSTM1和 GSTT1基因多态性与肝细胞癌风险的相关性 ,在广西黄曲霉毒素(AFB1)高污染区 ,用 PCR技术检测肝细胞癌患者和非肝细胞癌成人血样中 GSTM1和 GSTT1的存在或缺失。肝细胞癌组 (HCC) 181例 ,经病理确诊为肝细胞癌 ,对照组 36 0例 ,由非肝细胞癌成人组成。结果显示 ,GSTM1和 GSTT1零基因型的频率在对照组分别为 4 7.8%和 4 2 .7% ,在肝细胞癌组分别为 6 4 .6 %和 5 9.7% ,两组间的差异有非常显著性意义 (P <0 .0 1)。GSTM1和 GSTT1联合零基因型在肝细胞癌组与对照组分别为 38.2 %和18.5 % ,两组间差异有显著性意义 (P <0 .0 5 )。说明 GSTM1和 GSTT1零基因型在当地与 AFB1诱发肝细胞癌的风险相互关联。The present study was undertaken to evaluate the association between GSTM1 and GSTT1 gene polymorphisms and risk of hepatocellular carcinoma.Cases and controls study the genetic polymorphisms of the genes at an aflatoxin high contaminated region in Guangxi.Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 and GSTT1 genes at the blood samples.The case group was composed of 181 patients of HCC identified by the pathologist and the control group was composed of 360 adults without any tumor.The frequencies of GSTM1 and GSTT1 null genotype in the control were 47.8% and 42.7% respectively,while in the HCC group were 64.6% and 59.7% respectively.The differences between HCC group and the control group were very significant,P<0.01.GSTM1 and GSTT1 combined null genotype in HCC group and control group were 38.2% and 18.5%,the difference was significant (P<0.05).The GSTM1 and GSTT1 null genotypes were associated with an increased risk of HCC in this AFB1 high contaminated region.

关 键 词:肝细胞癌 黄曲霉毒素B1 谷胱甘肽硫转移酶 

分 类 号:R737-33[医药卫生—肿瘤]

 

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