SREBP-2基因1784G>C位点多态性与血清脂质水平变化的关系  

THE RELATIONS BETWEEN SREBP-2 GENE 1784G>C POLYMORPHISM AND SERUM LIPIDS LEVELS

作　　者：段雪英[1] 朱文丽[1] 刀京晶[1] 李勇[1] 肖颖[1] 

机构地区：[1]北京大学公共卫生学院营养与食品卫生学系,北京100083

出　　处：《营养学报》2005年第2期96-100,共5页Acta Nutrimenta Sinica

基　　金：达能膳食营养研究与宣教基金(2000)

摘　　要：目的:为探讨固醇调节元件结合蛋白-2(SREBP-2)基因1784G>C位点多态性与高胆固醇血症人群膳食干预效果的关系。方法:从北京市西城区8个社区居民中筛出110名高胆固醇血症患者,按所在社区随机分为干预组(64人)和对照组(46人),对两组人群进行血脂谱水平检测、膳食调查、体格检查及SREBP-2基因1784G>C位点多态性检测(PCR-RFLP方法),并对干预组进行为期6个月的膳食干预。结果:与对照组相比,干预组干预后膳食结构趋向合理,血清TC、LDL-C和HDL-C水平明显下降(P<0.05),且SREBP-2基因1784G>C位点GG基因型携带者TC和LDL-C水平降低幅度大于GC/CC基因型。结论:本研究初步得出SREBP-2基因1784G>C位点多态性可部分解释高胆固醇血症人群膳食干预易感性的差异,但仍需进一步证实。Objective: To investigate the relations between Sterol- Regulatory Element-Binding Protein-2 (SREBP-2) gene 1784G>C polymorphism and dietary intervention predisposition in hypercholesterolaemia population. Methods : A total of 110 hypercholesterolaemia patients were selected from eight communities in Xicheng District of Beijing, and randomly divided into intervention group (n=64) and control group (n=46). The measurement of serum lipids profile, calculation of dietary intakes and physical examination were carried out in all subjects. Also the SREBP-2 gene 1784G>C polymorphisms were determined by PCR-RFLP method. Results: The dietary patterns were improved and the serum levels of TC, LDL-C and HDL-C were significantly decreased (P<0.05) after 6 months dietary intervention in the intervention group compared with the control group. The decrease range of TC and LDL-C in GG genotype carriers was much more than in GC/CC genotype. Conclusions: The serum TC and LDL-C cholesterol responsiveness to dietary change in hypercholesterolaemia population may be partly explained by variation at SREBP-2 gene 1784G>C polymorphism.

关 键 词：固醇调节元件结合蛋白-2 基因多态性 高胆固醇血症 膳食干预 

分 类 号：R589.2[医药卫生—内分泌]